The Journal of the Korea Contents Association (한국콘텐츠학회논문지)

The Korea Contents Association (한국콘텐츠학회)
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Protection Effect of Natual Matter and Radiation Damage on Kidney Tissue

신장 조직의 방사선 손상과 천연물질의 방어기전 연구

  • 지태정 (가야대학교 방사선학과)
  • Received : 2009.08.14
  • Accepted : 2009.10.08
  • Published : 2009.12.28
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Abstract

This research has microstructure observation to find tissue damage mechanism and radio-protection effect on mouse kidney tissue. The result observation of a Light Microscope(LM); The kidney tissue after 5Gy irradiation observed a glomerulus atrophy, also crack distance to base membrane of a convoluted tubules. The kidney tissue after 10Gy irradiation observed out flow cytoplasm to membrane break of a convoluted tubules. The result observation of a Transmission Electron Microscope(TEM); The kidney tissue of after 5Gy irradiation has to breaking a inside cristae and membrane of mitochondria, also show definite damage of nucleus membrane. 10Gy irradiation has all the more damage a base membrane and thickness of lysosome. However, Propolis eating groups observed normal to nucleus membrane and small body of intracellular. therefore We considered "Propolis" as make radio protection function to kidney tissue of the greater part.

본 연구는 방사선조사 후 신장 조직의 손상과 방어기전을 알아보고자 생쥐 모델을 이용하여 미세구조를 관찰하였다. 광학현미경(LM)의 관찰 결과; 5Gy 조사 후 10일된 신장 조직에서는 정상조직과 비교하여 사구체가 위축되었으며, 10Gy 관찰에서는 곱슬세관(convoluted tubules)의 막이 파괴되어 세포질이 유출되었다. 투과전자현미경(TEM) 관찰 결과; 5Gy 조사에서는 사립체의 막이 파괴되거나 함몰된 것으로 관찰되었으며, 내부 크리스테의 형태도 소실되었다. 또한 일부에서는 핵막의 파괴도 확인되었다. 10Gy 조사한 조직에서는 기저막의 파괴가 뚜렷하게 관찰되고, 용해소체도 비후 된 것을 관찰하였다. 하지만 프로폴리스 섭식한 실험 군에서는 소기관의 형태가 뚜렷하게 관찰되었고, 핵막과 염색질도 선명하게 관찰되어 방어효과를 확인할 수 있었다.

Keywords

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