Role of Autophagy in the Control of Cell Death and Inflammation

  • Lee, Myung-Shik (Department of Medicine, Samsung Medical Center, Sungkyunkwan University)
  • Published : 2009.02.28

Abstract

There is mounting evidence that autophagy is involved in diverse physiological and pathological processes that have immense relevance in human development, diseases and aging. Immunity and inflammation are not exceptions. Here, the role of autophagy in the control of immune processes particularly that related to cell death and inflammation is discussed.

Keywords

References

  1. Levine B, Kroemer G: Autophagy in pathogenesis of disease. Cell 132;27-42, 2008 https://doi.org/10.1016/j.cell.2007.12.018
  2. Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, Gilpin C, Levine B: Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 128;931-946, 2007 https://doi.org/10.1016/j.cell.2006.12.044
  3. Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T: Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169;425-434, 2005 https://doi.org/10.1083/jcb.200412022
  4. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N: Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441;885-889, 2006 https://doi.org/10.1038/nature04724
  5. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koide M, Uchiyama Y, Kominami E, Tanaka K: Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441;880-884, 2006 https://doi.org/10.1038/nature04723
  6. Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, Mizote I, Matsumura Y, Asahi M, Nishida K, Hori M, Mizushima N, Otsu K: The role of autophagy in cardiomyocytes in the basal state and in response to hemodynimic stress. Nat Med 13;619-624, 2007 https://doi.org/10.1038/nm1574
  7. Ogata M, Hino SI, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, Shiosaka S, Hammarback JA, Urano F, Imaizumi K: Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26;9220-9231, 2006 https://doi.org/10.1128/MCB.01453-06
  8. Kim EH, Sohn S, Kwon HJ, Kim SU, Kim MJ, Lee SJ, Choi KS: Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res 67;6314-6324, 2007 https://doi.org/10.1158/0008-5472.CAN-06-4217
  9. Park KJ, Lee SH, Kim TI, Lee HW, Lee CH, Kim EH, Jang JY, Choi KS, Kwon MH, Kim YS: A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells. Cancer Res 67;7327-7334, 2008 https://doi.org/10.1158/0008-5472.CAN-06-4766
  10. Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, CHoi B, Lee H, Kim JH, Mizushima N, Oshumi Y, Jung YK: Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formaion and cell death. J Biol Chem 280;20722-20729, 2005 https://doi.org/10.1074/jbc.M413934200
  11. Boya P, Gonalez-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Metivier D, Meley D, Souquere S, Yoshimori T, Pierron G, Codogno P, Kroemer G: Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 25;1025-1040, 2005 https://doi.org/10.1128/MCB.25.3.1025-1040.2005
  12. Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, Azuma K, Hirose T, Tanaka K, Kominami E, Kawamori R, Fujitani Y, Watada H: Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab 8;325-332, 2008 https://doi.org/10.1016/j.cmet.2008.08.009
  13. Jung HS, Chung KW, Won KJ, Kim J, Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon KH, Kim JW, Jeong YT, Han MS, Lee MK, Kim KW, Shin J, Lee MS: :Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab 8;318-324, 2008 https://doi.org/10.1016/j.cmet.2008.08.013
  14. Jung HS, Lee MS :Macroautophagy in homeostasis of pancreatic b-cells. Autophagy 5;1-3, 2009
  15. Maiuri MC, Zalckvar E, Kimchi A, Kroemer G: Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8;741-752, 2007 https://doi.org/10.1038/nrm2239
  16. Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, Mills GB: The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation modiating the decision to enter autophagy or apoptosis. Nat Cell Biol 9;218-224, 2007 https://doi.org/10.1038/ncb1537
  17. Ravikumar B, Berger Z, Vacher C, O'Kane CJ, Rubinsztein DC: Rapamycin pre-treatment protects against apoptosis. Hum Mol Genet 15;1209-1216, 2006 https://doi.org/10.1093/hmg/ddl036
  18. Degenhardr K, Marthew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gelinas C, Fan Y, Nelson DA, Jin S, White E: Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis, Cancer Cell 10;51-64, 2006 https://doi.org/10.1016/j.ccr.2006.06.001
  19. Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V: Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119;753-766, 2004 https://doi.org/10.1016/j.cell.2004.11.038
  20. Schmid D, Pypaert M, Munz C: Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity 26;79-92, 2007 https://doi.org/10.1016/j.immuni.2006.10.018
  21. Nedjic J, Aichinger M, Emmerich J, Mizushima N, Klein L: Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature 455;396-400, 2008 https://doi.org/10.1038/nature07208
  22. Feng CG, Zheng L, Jankovic D, Bafica A, Cannons JL, Watford WT, Chaussabel D, Hieny S, Caspar P, Schwartzberg PL, Lenardo MJ, Sher A: The immunity-related GTPase Irgml promotes the expansion of activated CD4+ T cell death. Nat Immunol 9;1279-1287, 2008 https://doi.org/10.1038/ni.1653
  23. Kim HS, Lee MS: Essential role of STATI in caspase-independent cell death of activated macrophages through the p38 mitogen activated protein kinase/STAT1/reactive oxygen species pathway. Mol Cell Biol 25;6821-6833, 2005 https://doi.org/10.1128/MCB.25.15.6821-6833.2005
  24. Xu Y, Kim SO, Li Y, Han J: Autophagy contributes to caspase-independent macrophage cell death. J Biol Chem. 281;19179-19187, 2006 https://doi.org/10.1074/jbc.M513377200
  25. Yu L, Wan F, Dutta S, Welsh S, Liu ZH, Freundt E, Baehrecke EH, Lenardo MJ: Autophagic programmed cell death by selective catalase degradation, Proc Natl Acad Sci U S A 103;4952-4957, 2006 https://doi.org/10.1073/pnas.0511288103
  26. Wu YT, Tan HL, Huang Q, Kim YS, Pan N, Ong WY, Liu ZG, Ong CN, Shen HM: Autophagy plays a protective role during zVAD-induced necrotic cell death. Autophagy 4;457-466, 2008 https://doi.org/10.4161/auto.5662
  27. Sanjuan MA, Dillon CP, Tait SWG, Moshiach S, Dorsey F, Connell S, Komatsu M, Tanaka K, Cleveland JC, Withoff S, Green DR: Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature 450;1253-1257, 2007 https://doi.org/10.1038/nature06421
  28. Xu Y, Jagannath C, Liu XD, Sharafkhaneh A, Kolodziejska KE, Eissa NT: Toll-like receptor 4 is a sensor for autophagy associatid with innate immunity. Immunity 27;135-144, 2007 https://doi.org/10.1016/j.immuni.2007.05.022
  29. Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S: Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456;264-269, 2008 https://doi.org/10.1038/nature07383
  30. Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M: Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta prosessing. Science 307;734-738, 2005 https://doi.org/10.1126/science.1103685
  31. Massey DC, Parkes M: Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease. Autophagy 3;649-651, 2007 https://doi.org/10.4161/auto.5075
  32. Vaishnava S, Behrandt CL, Ismail AS, Eckmann L, Hooper LV: Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal bost-microbial interface. Proc Natl Acad Sci U S A 105;20858-20863, 2008 https://doi.org/10.1073/pnas.0808723105
  33. Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th: A key role for autophagy and the autophagy gene Arg1611 in mouse and human intestinal Paneth cells. Nature 456;259-264, 2008 https://doi.org/10.1038/nature07416