Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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Immunohistochemistry of CK7, CK19, CK20, SMA and Ki-67 Expression in Adenoid Cystic Carcinoma of the Head and Neck

두경부 영역에 발생한 선양낭성암종에서 CK7, CK19, CK20, SMA 및 Ki-67의 발현에 관한 면역조직화학적 연구

  • Moon, Young-Eun (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chungbuk National University) ;
  • Jeong, Woo-Jin (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chungbuk National University) ;
  • Lee, Dong-Wook (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chungbuk National University) ;
  • Song, Hyung-Geun (Department of Pathology, College of Medicine, Chungbuk National University)
  • 문영은 (충북대학교 의과대학 이비인후과학교실) ;
  • 정우진 (충북대학교 의과대학 이비인후과학교실) ;
  • 이동욱 (충북대학교 의과대학 이비인후과학교실) ;
  • 송형근 (충북대학교 의과대학 병리학교실)
  • Published : 2009.11.30
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Abstract

Objectives : The aim of this study was to investigate immunohistochemical expression of CK7, CK19, CK20, SMA and Ki-67 in Adenoid cystic carcinoma(ACC) of the Head and Neck. Material and Methods : Sixteen patients who were treated in Chungbuk National University Hospital from 1992 to 2004, were included in this study. Ten ACCs, 3 MECs, 1 Salivary duct carcinoma, 1 Adenocarcinoma(NOS), and 1 cacinoma ex pleomorphic adenoma were analyzed immunohistochemically for CK7, CK19, CK20, SMA, and Ki-67. Results : CK7 was expressed in 100% of the adenoid cystic carcinoma and 75% of the other tumors. CK19 was expressed in 75% of the adenoid cystic carcinoma and 100% of the other tumors. CK20 was not expressed in all tumors. SMA was expressed in 88.9% of the adenoid cystic carcinoma and not expressed in the other tumors. Ki-67 was expressed in low level in the adenoid cystic carcinoma. Conclusion : The Ki-67 index could explain the natural course of tumor. Immunohistochemistry of CK7, CK19, CK20, SMA and Ki-67 expression in Adenoid cystic carcinoma may provide useful information to diagnosis.

Keywords

References

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