Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effects of Gardeniae Fructus on Corticotropin-Releasing Factor, c-fos and Tyrosine Hydroxylase in Forced Swimming Test

치자(梔子)가 강제수영부하시험에서 Corticotropin-Releasing Factor, c-fos와 Tyrosine Hydroxylase에 미치는 영향

  • Park, Chan-Hyuck (Dept. of Formulae Pharmacology, College of Oriental Medicine, Kyungwon University) ;
  • Lee, Tae-Hee (Dept. of Formulae Pharmacology, College of Oriental Medicine, Kyungwon University)
  • 박찬혁 (경원대학교 한의과대학 방제학교실) ;
  • 이태희 (경원대학교 한의과대학 방제학교실)
  • Published : 2009.06.30
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Abstract

Objectives : The goal of this study was to investigative the effect of Gardeniae Fructus (GF)as antidepressant in the forced swimming test(FST) model rats. Methods : The expressions of corticotropin-releasing factor(CRF), tyrosine hydroxylase (TH) and c-fos were measured by immunohistochemical method at paraventricular nucleus(PVN), locus coeruleus (LC) and ventral tegmental area(VTA). Results : The duration of immobility in FST was significantly decreased in the GF 100mg/kg groups (p<0.05). CRF expression was significantly decreased at PVN in the GF 100 mg/kg and 400mg/kg treated group in comparison with the control group, respectively (p<0.01). c-fos expression was decreased at PVN in the GF 100 mg/kg treated group with no significance. TH expression was significantly decreased in the GF 100 mg/kg and 400mg/kg treated group in comparison with the control group, at LC and VTA respectively (p<0.001). Conclusion : According to the results, it can be considered that Gardeniae Fructus has antidepressant effect by showing the reduction of immobility in FST through the reduction of CRF, TH expression.

Keywords

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