YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Cell Surface Expression of H2-M3 Does Not Directly Effect on the Killing Activity of NK Cell

H2-M3의 세포 표면 발현이 NK 세포의 활성에 미치는 영향 분석

  • Lee, Sang-Yeol (Department of Life Science, College of Natural Sciences, Kyungwon University) ;
  • Chun, Tae-Hoon (College of Life Sciences and Biotechnology, Korea University)
  • 이상열 (경원대학교 자연과학대학 생명과학과) ;
  • 전태훈 (고려대학교 생명과학대학)
  • Published : 2009.06.30
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Abstract

H2-M3 (M3) is a unique antigen presenting molecule which provides N-formylated peptide to certain type of T cells. Previous observation indicated that NK cell activity is significantly diminished during listerial infection in $H2-M3^{-/-}$ mice. To explore the possibility that M3 expression directly effect on NK cell activity, we measured NK cell activity with or without stimulation of N-formylated peptide on antigen presenting cells. Results indicated that the expression of M3 is not directly influence on NK cell activity. Further study will be focused on the indirect effect of M3 on regulating NK cell activity.

Keywords

References

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