The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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The Anti-allergy Effects of Injinho-tang on the RBL-2H3 cells

RBL-2H3 cells에서의 인진호탕(茵蔯蒿湯)의 항 알레르기 효과

  • Eo, Kyeong-Jeong (Clinical Research Center Of Oriental Medicine, Department of Oriental Medicine, College of Oriental Medicine, Dongeui University) ;
  • Lyu, Ji-Hyo (Clinical Research Center Of Oriental Medicine, Department of Oriental Medicine, College of Oriental Medicine, Dongeui University) ;
  • Lyu, Sun-Ae (Clinical Research Center Of Oriental Medicine, Department of Oriental Medicine, College of Oriental Medicine, Dongeui University) ;
  • Yoon, Hwa-Jung (Clinical Research Center Of Oriental Medicine, Department of Oriental Medicine, College of Oriental Medicine, Dongeui University) ;
  • Ko, Woo-Shin (Clinical Research Center Of Oriental Medicine, Department of Oriental Medicine, College of Oriental Medicine, Dongeui University)
  • Published : 2009.04.25
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Abstract

인진호탕(茵蔯蒿湯)은 한의학에서 여러 가지 질환에 사용되어 왔다. 특히 간경의 습열(濕熱)로 인한 질환에 습열을 제거함으로써 증(證)의 완화에 많은 응용이 되어 왔다. 본 연구는 습열(濕熱)로 인한 질환중의 하나인 아토피 피부염에 그동안 응용이 적은 인진호탕(茵蔯蒿湯)을 실험적으로 응용함으로써 임상적인 가치를 가질 수 있는 지에 대한 기초연구를 진행하였다. 본 실험에 사용된 세포주는 rat leukemia (RBL-2H3) cells로 인진호탕(茵蔯蒿湯)은 알레르기와 관련된 사이토카인인 tumor necrosis factor (TNF)-$\alpha$, interleukin (IL)-4를 용량의존적으로 억제하였지만 세포독성은 일으키지 않았다. 그리고 동물실험에서 인진호탕(茵蔯蒿湯)은 PCA반응에서 충분한 억제효과를 나타내었다. 또한 Compound 48/80으로 유도된 anaphylaxis shock도 용량 의존적으로 억제함이 밝혀졌다.

Keywords

References

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