외과적 치료를 시행한 대량 일차성 자연기흉의 임상분석

Clinical Analysis of the Surgical Treatments for Large Primary Spontaneous Pneumothorax

  • 김병호 (대구파티마병원 흉부외과) ;
  • 허동명 (대구파티마병원 흉부외과) ;
  • 한원경 (대구파티마병원 흉부외과)
  • Kim, Byung-Ho (Department of Thoracic and Cardiovascular Surgery, Daegu Fatima Hospital) ;
  • Huh, Dong-Myung (Department of Thoracic and Cardiovascular Surgery, Daegu Fatima Hospital) ;
  • Han, Won-Kyung (Department of Thoracic and Cardiovascular Surgery, Daegu Fatima Hospital)
  • 발행 : 2009.06.05

초록

배경: 기흉 환자에 있어서 임상양상은 기흉의 양과 폐의 상태에 많은 영향을 받는다. 따라서 기존 폐질환이 없는 일차성 자연 기흉에서의 대량 기흉은 증상이 심할 수 있으므로 적극적인 치료가 필요할 것이다. 그러나 대량 기흉에 있어서의 치료 방침이 병원마다 다양하다. 따라서 외과적 치료를 시행한 일차성 자연기흉 환자의 임상소견을 분석하여 향후 치료의 지표로 삼고자 한다. 대상 및 방법: 2004년 8월부터 2007년 12월까지 일차성 자연기흉으로 치료를 시행한 348명의 환자 중 대량 기흉 환자 58명을 대상으로 후향적 조사를 통하여 흉강경소견 및 치료 결과를 분석하였다. 긴장성 기흉을 포함하여 흉부엑스선상 기흉의 양이 80% 이상인 경우를 대량 기흉으로 분류하였다. 이들 모두에게 12 F 흉관을 이용한 흉관삽입술을 먼저 시행하였다. 재발성, 지속적인 공기누출, 반대편 기흉의 과거력이 있는 경우에는 수술적 치료를 시행하였고, 초발인 경우에는 흉부단층촬영 소견상 1 cm 이상의 폐기 포가 관찰되었을 때 흉강내시경을 이용한 수술적 치료를 시행하였다. 결과: 대상환자는 남자 50명, 여자 8명 이었고, 평균 연령은 28.2세$(14\sim54)$였다. 평균 입원기간은 5.3일$(2\sim10)$이었다. 49예에서 흉강내시경 수술을 시행하였고 총판치료만 시행한 경우는 9예였다. 추적기간은 평균 27.8개월$(10\sim58)$ 이었다. 술 장에서의 공기누출은 35예(71.4%)에서 관찰되었으며, 공기누출에 영향을 주는 인자를 분석한 결과 흉막유착과 유의한 상관관계를 보였다(p=0.005). 술 전 공기누출이 있는 경우 술 장에서 공기누출이 발견된 경우가 많았으나 통계적 유의성은 없었다(p=0.066). 재발율은 흉관 삽입치료를 시행한 9예 중 1예(11.1%), 수술을 시행한 49예 중 1예(2.0%)였다. 결론: 대량 일차성 자연기흉은 조기 진단 및 조기 치료가 필요하다. 흉강내시경 수술이 대량 기흉의 치료 후 재발을 방지하는데 많은 도움이 될 것이다.

Background: The clinical history and physical findings of the patients with spontaneous pneumothorax depend largely on the extent of the collapse of the lung and the presence of pre-existing pulmonary disease. Large primary spontaneous pneumothorax is a possible serious condition and. so more active treatment will be necessary for these patients. The therapeutic guideline for large pneumothorax remains controversial. Therefore, by assessing the clinical results of surgical treatment for large primary pneumothorax, we aim to determine the indicators of treatment. Material and Method: Among 348 patients with primary spontaneous pneumothorax and who underwent surgical treatment from August 2004 through December 2007, 58 patients who responded to treatment for a large primary pneumothorax were included in the current study. We then retrospectively evaluated the operative findings and the surgical results. The patients with a pneumothorax of 80% or more, including those patients with tension pneumothorax, were considered to have a "large pneumothorax". Most of these patients Should be treated with a 12F chest tube. Thoracoscopic wedge resection was considered for treating recurrent pneumothorax, continuous air leakage, controlateral pneumothorax and first episode pneumothorax with visible blebs (> 1cm) seen on the computed tomography. Result: There were 50 men and 8 women with a mean age of 28.2 years (range: $14\sim54$ years). The mean length of hospitalization was 5.3 days (range: $2\sim10$ days). Nine patients underwent chest tube drainage only. Forty-nine patients underwent thoracoscopic wedge resection. The mean follow up time was 27.8 months (range: $10\sim58$ months). The actual site of air leakage could be located in 35 patients (71.4%) and this was correlated with pleural adhesion (p=0.005). The initial air leakage tended to be more correlated with intra-operative air leakage, although this was not statistically significant (p=0.066). The recurrence rate was 11.1 % for the patients with chest tube drainage and 2.0% for the patients with thoracoscopic wedge resection. Conclusion: Large primary pneumothorax requires an early diagnosis and early treatment. Thoracoscopic wedge resection may help to prevent recurrence of large primary pneumothorax.

키워드

참고문헌

  1. Light RW. Pneumothorax: pleural diseases. 3rd ed. Baltimore: Williams & Wilkins. 1995;242-77
  2. Baumann MH, Strange C, Heffner JE, et al. Management of spontaneous pneumothorax: an american college of chest physicians delphi consensus statement. Chest 2001;119:590- 602 https://doi.org/10.1378/chest.119.2.590
  3. Henry M, Arnold T, Harvey J. BTS guidelines for the management of spontaneous pneumothorax. Thorax 2003;58; ii39-52 https://doi.org/10.1136/thx.58.suppl_2.ii39
  4. Rivas JJ, Marcelo F, Molins L, Alfonso PT, Lanzas JT. Recommendations of the spanish society of pulmonology and thoracic surgery (SEPAR) Guidelines for the diagnosis and treatment of spontaneous pneumothorax. Arch Bronconeumol 2008;44:437-48
  5. Rhea JT, DeLuca SA, Greene RE. Determining the size of pneumothorax in the upright patient. Radiology 1982;144: 733-6 https://doi.org/10.1148/radiology.144.4.7111716
  6. Noppen M, Alexander P, Driesen P, Slabbynck H, Verstraete A. Quantification of the size of primary spontaneous pneumothorax: accuracy of the Light index. Respiration 2001;68: 396-9 https://doi.org/10.1159/000050533
  7. Collins CD, Lopez A, Mathie A, Wood V, Jackson JE, Roddei ME. Quantification of pneumothorax size on chest radiographs using interpleural distances:regression analysis based on volume measurements from Helical CT. AJR 1995;165:1127-30 https://doi.org/10.2214/ajr.165.5.7572489
  8. Lee DH. 알기쉬운 가슴외과학. 1판. 서울: 큐라인. 2006
  9. Kelly AM, Druda D. Comparison of size classification of primary spontaneous pneumothorax by three international guidelines: a case for international consensus? Respir Med 2008;102:1830-2 https://doi.org/10.1016/j.rmed.2008.07.026
  10. Noppen M. Pneumothorax size. Respir Med 2006;100:1475 https://doi.org/10.1016/j.rmed.2006.03.042
  11. Papakonstantinou DK, Gatzioufas ZI, Tzegas GI, et al. Unilateral pulmonary oedema due to lung re-expansion following pleurocentesis for spontaneous pneumothorax. The role of non-invasive continuous positive airway pressure ventilation. Int J Cardiol 2007;114:398-400 https://doi.org/10.1016/j.ijcard.2005.11.084
  12. Ayed AK, Chandrasekaran C, Sukumar M. Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax: clinicopathological correlation. Eur J Cardiothorac Surg 2006;29:221-5 https://doi.org/10.1016/j.ejcts.2005.11.005
  13. Warner BW, Bailey WW, Shipley RT. Value of computed tomography of the lung in the management of primary spontaneous pneumothorax. AJS 1991;162:39-42
  14. Ramos DM, Yepes VA, Sos JE, Tena JM, Sanchis JL. Usefulness of computed tomography in determining risk of recurrence after a first episode of primary spontaneous pneumothorax: therapeutic implications. Arch Bronconeumol 2007;43:304-8 https://doi.org/10.1016/S1579-2129(07)60075-5
  15. Kim MH, Lee CJ, Kim SW. Assessment of primary spontaneous pneumothorax using chest computerized axial tomography. Korean J Thorac Cardiovasc Surg 1993;26:209-13
  16. Chen JS, Hsu HH, Tsai KT, Yuan A, Chen WJ, Lee YC. Salvage for unsuccessful aspiration of primary spontaneous pneumothorax:thoracoscopic surgery or chest tube drainage? Ann Thorac Surg 2008;85:1908-13 https://doi.org/10.1016/j.athoracsur.2008.02.038
  17. Chan SS. The role of simple aspiration in the management of primary spontaneous pneumothorax. J Emerg Med 2008; 34:131-8 https://doi.org/10.1016/j.jemermed.2007.05.040
  18. Schramel FM, Postmus PE, Vanderschueren RG. Current aspects of spontaneous pneumothorax. Eur Respir J 1997;10:1372-9 https://doi.org/10.1183/09031936.97.10061372