Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
권호 표지

수열합성법으로 제조된 Zn-$TiO_2$ 나노입자와 $TiO_2$ 나노입자가 zebrafish 배발생에 미치는 영향

The Effect of Nano-scale Zn-$TiO_2$ and Pure $TiO_2$ Particles were Prepared using a Hydrothermal Method on Zebrafish Embryogenesis

  • 여민경 (경희대학교 공과대학 환경학과 환경연구센터) ;
  • 김효은 (경희대학교 공과대학 환경학과 환경연구센터)
  • Yeo, Min-Kyeong (Department of Environmental Science and Environmental Research Center, College of Engineering, Kyung Hee University) ;
  • Kim, Hyo-Eun (Department of Environmental Science and Environmental Research Center, College of Engineering, Kyung Hee University)
  • 발행 : 2009.12.31
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초록

In this study, we investigated the biological toxicity of nano-scale Zn (0.1, 0.5, and 1 mol%)-doped $TiO_2$ and pure $TiO_2$ nanoparticles using zebrafish embryogenesis as our model organism. Zn-doped $TiO_2$ nanoparticles were prepared using a conventional hydrothermal method for the insertion of zinc into the $TiO_2$ framework. The characters of Zn-doped $TiO_2$ (0.1%, 0.5%, 1%Zn) and pure $TiO_2$ were about 7~8 nm. These sizes were smaller than 100~200 nm of $TiO_2$ was prepared using the sol-gel method. Particularly, in this study, we found no significant biological toxicity in the hatching rate and abnormal rate under expose pure $TiO_2$ and Zn-doped $TiO_2$ nanoparticles were prepared using a conventional hydrothermal method of zebrafish. It was different from the biological damage under $TiO_2$ nanoparticles were prepared using sol-gel method. We assessed that the damage was not linked to the particle's nanometer size, but rather due to the prepare method. Moreover, $TiO_2$ nanoparticles were prepared using a hydrothermal method were not shown to cause cytotoxic effects, like apoptosis and necrosis, that are the major markers of toxicity in organisms exposed to nanomaterials. Therefore, there is some relationship with biological toxicity of nanoparticles and the prepare method of nanometer size particles.

키워드

참고문헌

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