Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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Evaluation of Hepatic Antioxidant Defense Systems in Rats Treated with Tetrabromobisphenol-A

Tetrabromobisphenol-A가 처리된 랫드의 간에서 항산화활성 평가

  • Lee, Sang-Yoon (College of Pharmacy and RCTCP, Chungnam National University) ;
  • Yun, Kang-Uk (College of Pharmacy and RCTCP, Chungnam National University) ;
  • Park, Sun-Hong (College of Pharmacy and RCTCP, Chungnam National University) ;
  • Jung, Sun-Ki (College of Pharmacy and RCTCP, Chungnam National University) ;
  • Kang, Keon-Wook (College of Pharmacy, Chosun University) ;
  • Jeong, Tae-Cheon (College of Pharmacy, Yeungnam University) ;
  • Kim, Hyung-Sik (College of Pharmacy, Pusan National University) ;
  • Jeong, Hye-Gwang (College of Pharmacy and RCTCP, Chungnam National University) ;
  • Kim, Bong-Hee (College of Pharmacy and RCTCP, Chungnam National University) ;
  • Kim, Sang-Kyum (College of Pharmacy and RCTCP, Chungnam National University)
  • 이상윤 (충남대학교 약학대학 형질전환 복제돼지센터) ;
  • 윤강욱 (충남대학교 약학대학 형질전환 복제돼지센터) ;
  • 박선홍 (충남대학교 약학대학 형질전환 복제돼지센터) ;
  • 정선기 (충남대학교 약학대학 형질전환 복제돼지센터) ;
  • 강건욱 (조선대학교 약학대학) ;
  • 정태천 (영남대학교 약학대학) ;
  • 김형식 (부산대학교 약학대학) ;
  • 정혜광 (충남대학교 약학대학 형질전환 복제돼지센터) ;
  • 김봉희 (충남대학교 약학대학 형질전환 복제돼지센터) ;
  • 김상겸 (충남대학교 약학대학 형질전환 복제돼지센터)
  • Published : 2009.12.31
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Abstract

Hepatic antioxidant defense systems were examined in rats treated with tetrabromobisphenol-A (TBBPA), a brominated flame retardant, at the doses of 0, 250, 500 and 1,000 mg/kg for four weeks. Hepatic ratio of glutathione disulfide to glutathione (GSH) and levels of malondialdehyde, oxidative stress markers were not changed in rats treated with TBBPA. Hepatic expression of antioxidant enzymes including GSH peroxdiase-1 (GPX-1)/GSH reductase (GR), alpha-, mu- and pi-class glutathione-S-transferase (GST) and gamma-glutamylcysteine ligase catalytic subunit was determined using immunoblot analysis. Alpha-class GSTs, GPX-1 and GR levels were significantly decreased in rats treated with TBBPA at the dose of 500 or 1,000 mg/kg. These results show that TBBPA results in down-regulation of hepatic expression of antioxidant enzymes related with GSH, suggesting the liver in TBBPA-treated rats may be more sensitive to oxidants.

Keywords

References

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