ORAL MANIFESTATION AND TREATMENT OF ACUTE MYELOID LEUKEMIA: A CASE REPORT

급성 골수성 백혈병의 구강 내 발현 및 치료: 증례 보고

  • Kim, Ji-Youn (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Min, Seung-Ki (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Lim, Ho-Kyung (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Suh, Jin-Won (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Hwang, Soon-Jung (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University)
  • 김지연 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 민승기 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 임호경 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 서진원 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 황순정 (서울대학교 치의학대학원 구강악안면외과학교실)
  • Received : 2009.08.10
  • Accepted : 2009.11.12
  • Published : 2009.11.20

Abstract

Proliferation of abnormal hematopoietic cells with impaired differentiation, regulation and programmed cell death leads to leukemia. AML(acute myeloid leukemia) is a malignancy with malfunction of myeloid hematopoietic cells with acute behavior. The oral manifestations of the disease are posterior palate hemorrhage, gingival bleeding and gingival ulceration as a result of infection by normal oral flora and gingival infiltration by leukemic cells. A 49-year-old male patient was referred from local dental clinic. The patient was diagnosed with AML FAB M1 (acute myeloid leukemia French-American-British classification M1 myeloblastic leukemia without maturation). The oral infection focus was removed by a conservative treatment. 2 days after the dental treatment, the patient underwent chemotherapy. At 8-month follow-up, the overall outcome was excellent. Oral manifestations of AML are often the first indications of the malignancy. Therefore it is essential for dentists, especially oral and maxillofacial surgeons, to be aware of the diagnostic signs and complications associated with leukemia for better diagnosis and subsequent treatment and management.

Keywords

References

  1. Burke VP, Startzell JM : The leukemias. Oral Maxillofac Surg Clin North Am 20 : 597, 2008 https://doi.org/10.1016/j.coms.2008.06.011
  2. Neville BW DD, Allen CM, Bouquot JE : Oral & Maxillofacial Pathology, 2nd ed. Philadelphia, WB Saunders, 2002, p.626
  3. Cho SY, Cheng AC, Cheng MC : Oral care for children with leukaemia. Hong Kong Med J 6 : 203, 2000
  4. Fauci AS, Braunwald E, Kasper DL et al : Harrison's Principles of Internal Medicine, 17th ed. the United States of America, the McGraw-Hill, 2008, p.677
  5. Seoul National University College of Medicine : Hematology, Seoul, Seoul National University Press, 1999, p.155
  6. Wu J, Fantasia JE, Kaplan R : Oral manifestations of acute myelomonocytic leukemia: a case report and review of the classification of leukemias. J Periodontol 73 : 664, 2002 https://doi.org/10.1902/jop.2002.73.6.664
  7. Koulocheris P, Metzger MC, Kesting MR et al : Lifethreatening complications associated with acute monocytic leukaemia after dental treatment. Aust Dent J 54 : 45, 2009 https://doi.org/10.1111/j.1834-7819.2008.01087.x
  8. Stafford R, Sonis S, Lockhart P et al : Oral pathoses as diagnostic indicators in leukemia. Oral Surg Oral Med Oral Pathol 50 : 134, 1980 https://doi.org/10.1016/0030-4220(80)90200-5
  9. Bodey GP : Oral complications of the myeloproliferative diseases. Postgrad Med 49 : 115, 1971 https://doi.org/10.1080/00325481.1971.11696477
  10. Demirer S, Ozdemir H, Sencan M et al : Gingival hyperplasia as an early diagnostic oral manifestation in acute monocytic leukemia: a case report. Eur J Dent 1 : 111, 2007
  11. Chi JH, Yeo HH, Kim YK et al : Leukemia : a case report. J Kor Oral Maxillofac Surg 22 : 230, 1996
  12. Salisbury PL, 3rd, Caloss R, Jr., Cruz JM et al : Mucormycosis of the mandible after dental extractions in a patient with acute myelogenous leukemia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 83 : 340, 1997 https://doi.org/10.1016/S1079-2104(97)90240-7
  13. Kim BG, Kim SG, Yeo HH et al : Osteomyelitis occurring leukemia patient: a case report. J Kor Oral Maxillofac Surg 26 : 310, 2000
  14. Kennedy HF, Morrison D, Tomlinson D et al : Gingivitis and toothbrushes: potential roles in viridans streptococcal bacteraemia. J Infect 46 : 67, 2003 https://doi.org/10.1053/jinf.2002.1084
  15. An updated legal perspective on antibiotic prophylaxis : American Dental Association Division of Legal Affairs. J Am Dent Assoc 139 Suppl : 10S, 2008 https://doi.org/10.14219/jada.archive.2008.0345