Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Prediction of Pregnancy Outcomes by Uterine Artery Impedances on the Day of Embryo Transfer in Human IVF

인간 체외수정술에서 배아 이식일의 자궁동맥 임피던스에 따른 임신의 예측

  • Jeong, Ju-Eun (Department of Obstetrics and Gynecology, Pusan National University, School of Medicine,Medical Research Institute, Pusan National University) ;
  • Jo, Moo-Sung (Department of Obstetrics and Gynecology, Pusan National University, School of Medicine,Medical Research Institute, Pusan National University) ;
  • Kim, Seung-Chul (Department of Obstetrics and Gynecology, Pusan National University, School of Medicine,Medical Research Institute, Pusan National University) ;
  • Joo, Jong-Kil (Department of Obstetrics and Gynecology, Pusan National University, School of Medicine,Medical Research Institute, Pusan National University) ;
  • Choi, Jong-Ryeol (Department of Obstetrics and Gynecology, Pusan National University, School of Medicine,Medical Research Institute, Pusan National University) ;
  • Lee, Kyu-Sup (Department of Obstetrics and Gynecology, Pusan National University, School of Medicine,Medical Research Institute, Pusan National University)
  • 정주은 (부산대학교 의학전문대학원 산부인과학교실) ;
  • 조무성 (부산대학교 의학전문대학원 산부인과학교실) ;
  • 김승철 (부산대학교 의학전문대학원 산부인과학교실) ;
  • 주종길 (부산대학교 의학전문대학원 산부인과학교실) ;
  • 최종열 (부산대학교 의학전문대학원 산부인과학교실) ;
  • 이규섭 (부산대학교 의학전문대학원 산부인과학교실)
  • Published : 2009.12.30
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Abstract

Objective: This study was aimed to investigate whether uterine blood flow on the day of embryo transfer can be a predictor of pregnancy outcome in human IVF. Methods: Fifty-one patients undergoing IVF program were included in this study. Serum estradiol levels were measured on the day of hCG administration and uterine pulsatility index (PI) and resistance index (RI) was examined for at embryo transfer of day 3. Results: Of 51 cycles, 22 cycles were clinically pregnant (43.1%) and the implantation rate was 14.7%. Uterine PI and RI had a significant inverse correlation with serum estradiol levels (p<0.05). These uterine blood flows were not significantly different between pregnant and nonpregnant groups. The pregnancy rate was slightly higher in patients with PI more than 3.0 compared to those with PI of 3.0 or less, but there was no significant difference. Conclusion: These results suggest that uterine PI and RI at the day of embryo transfer could not be a good predictor of pregnancy in IVF treatment. But they had an inverse correlation with serum estradiol levels on the day of hCG administration.

목 적: 본 연구는 배아이식일의 자궁동맥혈류가 인간 체외수정술에서 임신예후의 예측인자가 될 수 있는지 알아보기 위해 시행되었다. 연구방법: 51회의 체외수정술 주기에 대해 전향적인 임상 관찰로 시행되었으며 혈청 estradiol 농도는 hCG 투여일에 측정되었고, 자궁동맥 박동율 (PI)과 저항율 (RI)은 배아이식 3일째에 측정되었다. 결 과: 51회의 주기 중 22주기에서 임상적으로 임신이 확인되었고 (43.1%), 착상률은 14.7%였다. 자궁동맥 PI와 RI는 혈청 estradiol 농도과 의미 있는 음의 상관관계 (p<0.05)를 보였으며 자궁혈류량은 임신된 그룹과 임신 되지 않은 그룹에서 차이가 없었다. 임신율은 PI가 3.0 이상인 군에서 PI가 3.0 이하인 군보다 조금 높게 측정되었으나 통계학적인 유의성은 없었다. 결 론: 배아이식일의 자궁동맥 PI와 RI는 체외수정술에서 임신의 예측인자로는 효용성이 떨어지지만 estradiol 농도와는 음의 상관관계를 보여 자궁혈류와 estradiol 농도가 상관관계가 있음을 알 수 있다.

Keywords

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