Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Anti-cancer effect of Eriocaulon sieboldianum through the activation of caspase-3 in human leukemia cell line, HL-60 cells

  • Kim, Su-Jin (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Lee, Gi-Tak (College of Oriental Medicine, Wonkwang University) ;
  • Lee, Bo-Ra (College of Oriental Medicine, Wonkwang University) ;
  • Jeon, Kwon-Su (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Rim, Hong-Kun (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Bang, Jun-Ho (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Yang-Gwi (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Myung, No-Yil (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Moon, Phil-Dong (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Na-Hyung (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Choi, In-Young (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Choi, Young-Jin (Biochip Research Center, Hoseo University) ;
  • Kang, In-Cheol (Biochip Research Center, Hoseo University) ;
  • Um, Jae-Young (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Hong, Seung-Heon (College of Oriental Medicine, Wonkwang University) ;
  • Kim, Hyung-Min (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Jeong, Hyun-Ja (Biochip Research Center, Hoseo University)
  • Published : 2009.06.30
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Abstract

Eriocaulon sieboldianum (ES) is used in traditional oriental medicine for various medicinal purposes including headache, toothache, and inflammation. However, the anti-cancer effect of the ES is still not fully understood. In the present study, the human leukemia cell line HL-60 was used to characterize the apoptotic effects of ES. ES induced cytotoxicity of HL-60 cells in a dose- and time-dependent manner. ES induced the generation of reactive oxygen species, and the release of cytochrome c in a dose-dependent manner. In addition, we showed that ES-induced apoptosis was accompanied by activation of caspase-3. Taken together, our results demonstrate that ES possesses anti-cancer activity in HL-60 cells.

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References

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