Nuclear Medicine and Molecular Imaging

  • 제43권2호
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  • Pages.107-111
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  • 2009
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  • 1869-3474(pISSN)
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  • 1869-3482(eISSN)
대한핵의학회 (The Korean Society of Nuclear Medicine)
권호 표지

주 우울증 환자의 국소 뇌혈류 변화 연구

Alterations of Regional Cerebral Blood Flow in Major Depressive Disorder

  • 이원형 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 정용안 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 서예영 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 유익동 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 나세정 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 정현석 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 김기준 (가톨릭대학교 의과대학 방사선과학교실)
  • Lee, Won-Hyoung (Department of Radiology, College of Medicine, The Catholic University of Korea) ;
  • Chung, Yong-An (Department of Radiology, College of Medicine, The Catholic University of Korea) ;
  • Seo, Ye-Young (Department of Radiology, College of Medicine, The Catholic University of Korea) ;
  • Yoo, Ik-Dong (Department of Radiology, College of Medicine, The Catholic University of Korea) ;
  • Na, Sae-Jung (Department of Radiology, College of Medicine, The Catholic University of Korea) ;
  • Jung, Hyun-Suk (Department of Radiology, College of Medicine, The Catholic University of Korea) ;
  • Kim, Ki-Jun (Department of Radiology, College of Medicine, The Catholic University of Korea)
  • 발행 : 2009.04.30
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초록

목적: 저자 들은 주 우울증 환자들의 뇌 혈류 SPECT을 정상 대조군과 비교하여, 기존에 보고된 주 우울증 환자들의 소견과 어떤 차이가 있는 지 알아보고자 하였다. 대상과 방법: DSM-IV criteria로 주 우울증인 환자들 중에서 4주 이상 모든 정신과적 약물을 중지시킨 12명(남: 7, 녀: 5, 나이 범위: $19{\sim}52$세, 평균 나이: $29.3{\pm}9.9$세)과 자발적으로 지원한 정상 대조군 14명(남: 8, 녀: 6, 나이 범위: $19{\sim}53$세, 평균 나이: $31.4{\pm}9.2$세)을 대상으로 하였다. Tc-99m ECD 주사 후 SPECT 영상을 얻은 후, 주 우울증 환자군과 정상 대조군에서의 국소 뇌 혈류 패턴을 비교하였다. 결과: 정상인 대조군에 비해서, 주 우울증 환자들은 우측 후두엽의 설상 회와 방추상 회, 좌측 후두엽의 설상 회와 설전부, 그리고 좌측 측두엽의 상측두 회의 국소 뇌 혈류가 의미있게 증가하였다. 또한 우측 뇌교, 좌측 전두엽의 내측 전두회, 좌측 변연계의 대상 회, 우측 전두엽의 대상 회, 우측 변연계의 대상 회에서는 대조군에 비해 주 우울증 환자에서 국소 뇌 혈류가 의미있게 감소하였다. 결론: 주 우울증 환자군의 Tc-99m ECD뇌 혈류 SPECT 소견은 기존의 보고와 큰 차이가 없었으며, 우측 뇌교와 대상 회 그리고 좌측 내측 전두 회에서 특정적인 국소 뇌 혈류 감소 소견이 있었다.

Purpose: The authors analyzed how the regional cerebral blood flow(rCBF) findings of patients with major depression differ from the normal control, and our results were compared to previous reports. Materials and Methods: Twelve patients fulfilling DSM-IV criteria for major depression who were off all psychotropic medications for > 4weeks(male: 7, female: 5, age range: $19{\sim}52$ years, average age: $29.3{\pm}9.9$ years) and 14 normal volunteers(male: 8, female: 6, age range: $19{\sim}53$ years, average age: $31.4{\pm}9.2$ years) were recruited. Images of brain perfusion SPECT were obtained using Tc-99m ECD and patterns of the rCBF were compared between patients with major depression and the healthy control subjects. Results: The patients with major depression showed increase of the r-CBF in right lingual gyrus, right fusiform gyrus, left lingual gyrus, left precuneus, and left superior temporal gyrus, and showed decrease of r-CBF in right pons, left medial frontal gyrus, cingulate gyrus of left limbic lobe, cingulate gyrus of right frontal lobe, and cingulate gyrus of right limbic lobe compared to the normal control. Conclusion: The Tc-99m ECD brain perfusion SPECT findings in our study did not differ from the previously reported regional cerebral blood flow pattern of patients with major depression. Especially, decreased rCBF pattern typical to major depression patients in the right pons, left medial frontal gyrus, and cingulate regions was clearly demonstrated.

키워드

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