Childhood Kidney Diseases

Korean Society of Pediatric Nephrology (대한소아신장학회)
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Mini-review; Melamine-related Urinary Stone Disease

Mini-review: 멜라민에 의한 신요로계 결석

  • Kang, Hee-Gyung (Department of Pediatrics, College of Medicine, Seoul National University)
  • 강희경 (서울대학교병원 소아청소년과)
  • Published : 2009.04.30
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Abstract

Last year, an epidemic of infantile urinary stone disease developed in China. Investigation revealed that melamine-tainted diary product caused urinary stone in these infants. Young infants were susceptible to the melamine toxicity and dehydration or other stone-prone factors aggravated the toxicity. Melamine-related urinary stones were small, multiple, and mainly composed of uric acid, thus conservative treatment of hydration and urine alkalinization worked well in majority of the patients.

2008년 말 발생한 멜라민 파동은 멜라민에 오염된 분유를 섭취한 영아들에서 요로계 결석이 발생한 것으로부터 비롯되었다. 멜라민 관련 요로계 결석의 위험인자는 3세 미만의 나이, 많은 멜라민 섭취량과 탈수, 요산의 요 배설량 증가 등의 일반적인 요로계 결석 위험인자의 동반이다. 멜라민 관련 결석은 주 성분이 요산이므로 수분 공급과 소변 알칼리화의 보존적인 치료로 회복되는 경우가 대부분이다.

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References

  1. Zhang L, Wu LL, Wang YP, Liu AM, Zou CC, Zhao ZY. Melamine-contaminated milk products induced urinary tract calculi in children. World J Pediatr 2009;5:31-5. https://doi.org/10.1007/s12519-009-0005-6
  2. Lam CW, Lan L, Che X, Tam S, Wong SS, Chen Y, et al. Diagnosis and spectrum of melamine-related renal disease: plausible mechanism of stone formation in humans. Clin Chim Acta 2009;402:150-5. https://doi.org/10.1016/j.cca.2008.12.035
  3. Hau AK, Kwan TH, Li PK. Melamine toxicity and the kidney. J Am Soc Nephrol 2009;20:245-50. https://doi.org/10.1681/ASN.2008101065
  4. Guan N, Fan Q, Ding J, Zhao Y, Lu J, Xu G, et al. Melamine-contaminated powdered formula and urolithiasis in young children. N Engl J Med 2009;360:1067-74. https://doi.org/10.1056/NEJMoa0809550
  5. Jeong WI, Do SH, Jeong da H, Chung JY, Yang HJ, Yuan DW, et al. Canine renal failure syndrome in three dogs. J Vet Sci 2006:7:299-301. https://doi.org/10.4142/jvs.2006.7.3.299
  6. Melnick RL, Boorman GA, Haseman JK, Montali RJ, Huff J. Urolithiasis and bladder carcinogenicity of melamine in rodents. Toxicol Appl Pharmacol 1984;72:292-303. https://doi.org/10.1016/0041-008X(84)90314-4
  7. Ogasawara H, Imaida K, Ishiwata H, Toyoda K, Kawanishi T, Uneyama C, et al. Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation. Carcinogenesis 1995;16:2773-7. https://doi.org/10.1093/carcin/16.11.2773
  8. Ding J. Childhood urinary stones induced by melaminetainted formula: how much we know, how much we don't know. Kidney Int 2009;75:780-2. https://doi.org/10.1038/ki.2009.30
  9. Sun N, Shen Y, Sun Q, Li XR, Jia LQ, Zhang GJ, et al. [Melamine related urinary calculus and acute renal failure in infants]. Zhonghua Er Ke Za Zhi 2008;46:810-5.