Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
권호 표지

Effects of Achyrantes japonica on Carrageenan-Induced Arthritis Rat Model

Carrageenan으로 유발한 관절염 쥐에서의 우슬추출물 효과

  • 김영옥 (국립원예특작과학원 인삼특작부) ;
  • 이상원 (국립원예특작과학원 인삼특작부) ;
  • 이승은 (국립원예특작과학원 인삼특작부)
  • Published : 2009.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Achyrantes japonica (AJ) has been used to treat edema and arthritis in the traditional Korean medicine. To elucidate the anti-inflammatory and anti-nociceptive effects of ethanol extract of AJ, the carrageenan-induced paw edema using a plethysmometer and thermal hypersensitivity using the plantar test were measured. Ibuprofen was used as a control drug. Treatment with AJ (200mg/kg p.o.) significantly reduced paw edema, compared to the carrageenan - treated rats. In the plantar test, the thermal withdrawal latency in AJ - treated group was significantly increased than the carrageenan - treated group. The results indicate that AJ could have be the anti-inflammatory and anti-nociceptive properties.

Keywords

References

  1. An CS, Jin HL, Jeon YH and Lim BO. (2009). The protective effects of Scutellaria Bicalensis Georgi water extracts on the immunomodulatory effects on liver damage induced by carbon tetrachloride in rats. Korean Journal Medicinal Crop Science. 17:273-279
  2. Ballou LR, Botting RM, Goorha S, Zhang J and Vane JR. (2000). Nociception in cyclooxygenase isozyme-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 97:10272-10276 https://doi.org/10.1073/pnas.180319297
  3. Chan TF, HY Tsai and Tian - Shang, W. (1995). Antiinflammatory and analgesic activities from the roots of Angelica pubescens .Plant Medicine. 61:2-8 https://doi.org/10.1055/s-2006-957987
  4. Cheon MS, Yoon Taesook, Choi GY, Kim SJ, Lee AY, Moon BC, Choo BK and Kim HK. (2009). Comparative study of extracts from rhubarb on inflammatory activity in Raw 264.7 cells. Korean Journal Medicinal Crop Science. 17:109-114
  5. Collier HO, Dinneen LC, Johnson CA and Schneider C. (1968). The abdominal constriction response and its suppression by analgesic drugs in the mouse. British Journal of Pharmacology and Chemotherapy. 32:295-310 https://doi.org/10.1111/j.1476-5381.1968.tb00973.x
  6. Damas J, Remacle-Volon G and Deflandre E. (1986). Further studies of the mechanism of counter irritation by turpentine. Naunyn-Schmiedeberg's Archives of Pharmacology. 332:196-200 https://doi.org/10.1007/BF00511412
  7. Di Meglio P, Ianaro A and Ghosh S. (2005). Amelioration of acute inflammation by systemic administration of a cellpermeable peptide inhibitor of NF-kappaB activation. Arthritis and Rheumatism. 52:951-958 https://doi.org/10.1002/art.20960
  8. Joseph SM, George MC, Rajasekharan Nair, Priya Senan V, Pillai D and Sherief PM. (2005). Effect of feeding cuttlefish liver oil on immune function, inflammatory response and platelet aggregation in rats. Current Science. 88:507-511
  9. Kosuge T and Ishida H. (1985). Studies on active substances in the herbs used for oketsu(“stagnant blood”) in Chinese medicine. IV. On the anticoagulative principle in rhei rhizome. Chemical & Pharmaceutical Bulletin (Tokyo). 33:1503-1506 https://doi.org/10.1248/cpb.33.1503
  10. Pini LA, Vitale G, Ottani A and Sandrini M. (1997). Naloxonereversible antinociception by paracetamol in the rat. The Journal of Pharmacology and Experimental Therapeutics. 280:934-940
  11. Solano R. (1999). Response properties of hind limb single motor units in normal rats and after carrageenan-induced inflammation. Neuroscience. 90:1393-1402 https://doi.org/10.1016/S0306-4522(98)00549-1
  12. Winter CA, Risley EA and Nuss GW. (1962). Carrageenan induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proceedings of the Society for Experimental Biology and Medicine. 111: 544-547
  13. Yun-Choi HS, Kim SO, Kim JH, Lee JR and Cho HI. (1985). Modified smear method for screening potential inhibitors of platelet aggregation from plant sources. Journal of Natural Products. 48:363-370 https://doi.org/10.1021/np50039a003