Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Synergic Effect of Methanol extracts of Schizandrae Fructus and Mume Fructus on Experimental Mouse Colitis Induced by Dextran Sulfate Sodium

Dextran Sulfate Sodium 유도 마우스 대장염에 미치는 오미자와 매실의 상승효과

  • Jang, Seon-Il (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Mok, Ji-Ye (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Choi, Hyo-Jung (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Jeon, In-Hwa (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Lee, Kang-Soo (Faculty of Biological Resources Science, Jeonbuk National University) ;
  • Yun, Young-Gab (Department of Oriental Medical Prescription, Wonkwang University)
  • 장선일 (전주대학교 대체의학대학 건강관리) ;
  • 목지예 (전주대학교 대체의학대학 건강관리) ;
  • 최효정 (전주대학교 대체의학대학 건강관리) ;
  • 전인화 (전주대학교 대체의학대학 건강관리) ;
  • 이강수 (전북대학교 농업생명과학대학) ;
  • 윤용갑 (원광대학교 한의과대학 방제학교실)
  • Published : 2009.12.30
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Abstract

The fruits of Schisandra chinensis and Prunus mume have been traditionally used in the Oriental countries as an astringent against diarrhea and abdominal pain, a protectant for liver disease, an antimicrobial, and a blood tonic. However, little is known about the extract of Schizandrae Fructus and Mume Fructus (SMF-Ex) on dextran-sulfate sodium (DSS)-induced colitis in mice. In this study, we investigated the protective effects of SMF-Ex on DSS-induced colitis in mice. An experimental colitis was induced by daily treatment with 5% DSS. SMF-Ex was orally administrated the single dose (80 mg/kg, body weight/day) for 7 days with one time per day. SMF-Ex reduced significantly clinical sign of DSS-induced colitis, including body weight loss, shorten colon length, increased disease activity index (DAI), and histological colon injury. SMF-Ex also inhibited significantly nitric oxide (NO) and prostaglandine $E_2$ ($PGE_2$) productions in DSS-induced colitis mice. Furthermore, SMF-Ex increased significantly an superoxide anion (SOD), catalase, and glutathione peroxidase (Gpx) activity of the colon tissue in DSS-induced colitis mice. These results suggest that SMF-Ex administration could reduce significantly the clinical signs and inflammatory mediators, and increase antioxidant activity in DSS-induced colitis model mice and is a good candidate for further evaluation as an effective anti-ulcerative agent.

Keywords

References

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