Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
권호 표지

Concentration of Hazardous Substances of before/after a Decoction in Prescription of Herbal Medicine -In Prescription of tonify Yang and tonify Yin-

한방처방의 전탕 전과 후의 위해물질 농도변화 -보양.보음 처방을 중심으로 -

  • Seo, Chang-Seob (Division of Standard Research, Korea Institute of Oriental Medicine) ;
  • Huang, Dae-Sun (Division of Standard Research, Korea Institute of Oriental Medicine) ;
  • Lee, Jun-Kyoung (Division of Standard Research, Korea Institute of Oriental Medicine) ;
  • Ha, Hye-Kyoung (Division of Standard Research, Korea Institute of Oriental Medicine) ;
  • Chun, Jin-Mi (Division of Standard Research, Korea Institute of Oriental Medicine) ;
  • Um, Young-Ran (Division of TKM Integrated Research, Korea Institute of Oriental Medicine) ;
  • Jang, Seol (Herbal Quality Control Center, Korea Institute of Oriental Medicine) ;
  • Shin, Hyeun-Kyoo (Division of Standard Research, Korea Institute of Oriental Medicine)
  • 서창섭 (한국한의학연구원 표준화연구본부) ;
  • 황대선 (한국한의학연구원 표준화연구본부) ;
  • 이준경 (한국한의학연구원 표준화연구본부) ;
  • 하혜경 (한국한의학연구원 표준화연구본부) ;
  • 천진미 (한국한의학연구원 표준화연구본부) ;
  • 엄영란 (한국한의학연구원 한의융합연구본부) ;
  • 장설 (한국한의학연구원 한약품질관리센터) ;
  • 신현규 (한국한의학연구원 표준화연구본부)
  • Published : 2009.12.30
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Abstract

Objective : To compare the contents of heavy metals, residual pesticides and sulfur dioxide before/after a decoction. Methods : The heavy metal contents before/after a decoction were measured by Inductively Coupled Plasma Atomic Emission Spectrometer (ICP-AES) and mercury analyzer. In order to analyze pesticides in 4 samples we used simultaneous multi-residue analysis of pesticides by GC/ECD, which was followed by GC/MSD analysis to confirm the identity of the detected pesticide in each sample. In addition, the contents of sulfur dioxide ($SO_2$) were performed by Monier-Williams distillation method. Results: 1. The mean values of heavy metal contents (mg/kg) for the samples were as follows: Jaeumganghwa-tang (before decoction - Pb; 1.190, Cd; 0.184, As; 0.099 and Hg; 0.028, after decoction - Pb; .033, Cd; 0.003, As; 0.005 and Hg; 0.001), Yukmijiwhang-tang (before decoction - Pb; 0.484, Cd; 0.133, As; 0.053 and Hg; 0.009, after decoction - Pb; 0.065, Cd; 0.008, As; 0.007 and Hg; not detected), Bojungikgi-tang (before decoction - Pb; 0.863, Cd; 0.197, As; below 0.016 and Hg; 0.011, after decoction - Pb; 0.071, Cd; 0.009, As; 0.004 and Hg; 0.001) and Ssangwha-tang (before decoction - Pb; 1.511, Cd; 0.212, As; 0.094 and Hg; 0.016, after decoction - Pb; 0.029, Cd; 0.006, As; 0.005 and Hg; 0.0004). 2. Contents (mg/kg) of sulfur dioxide ($SO_2$) before a decoction in Jaeumganghwa-tang, Yukmijiwhang-tang and Ssangwha-tang exhibited 22.7, 107.3 and 5.5, respectively. However, contents of sulfur dioxide after a decoction in all samples were not detected. 3. Contents (mg/kg) of residual pesticides before/after a decoction in all samples were not detected. Conclusion : These results will be used to establish a criterion of heavy metals, residual pesticides and sulfur dioxide.

Keywords

References

  1. Oh CS, Seo DW, Yook CS, LeeYJ, Chang SY, Ze KR, Park JY, Lee JP, Seong RS, Park JY, Ko SK, LeePJ.Thevariation of residual sulfur dioxide and marker components of herbal medicines during drying process.Kor J Pharmacogn. 2007;38:299-304.
  2. Yim OK, Han EJ, Chung JY, Park KS, Kang IH, Kang SJ, Kim YJ.The monitoring of some heavy metals in oriental herbal medicines and their intake rates. Anal Sci Technol.2009 ;22:129-35
  3. Massaro EJ. Handbook of human toxicology. New York: Boca Raton Press.1990:149-88
  4. Lee BC. A study on the content of heavy metal in domestic or foreign oriental medicine by means of quantitative analytical method. Seoul:KyungHee Univ.1995
  5. WHO. Lead (Environmental Health Criteria 3). WHO.1997:44-54
  6. Conor R. Metal contamination of food. London :Applied Science Publisher LTD. 1980:119-22
  7. Conor R. Metal contamination of food. 2nd edition. London:Elsevier Science Publishers LTD.1991 :95-8.
  8. Codex Alimentarius Commission, Contaminants :Joint FAO/WHO food standards program. Codex Alimentarius.VolXVII,Rome.1984:1-3
  9. KFDA. A noticefrom 2008-2.Korea Food and Drug Administration.Seoul.2008
  10. Park SS. A study on the analysis of hazardous chemicals and metabolites of organophosphorous compounds in urine by GC/MS. Seoul:Konkuk Univ.1998.
  11. Rogan WJ, Gladen BC, McKinney JD, Carreras N, Hardy P, Thullen J, Tingelstad J,Tully M. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk:effects of maternal factors and previous lactation.Am J Public Health.1986 ;76:172-7.
  12. Schecter A, Li L. Dioxins, dibenzofurans, dioxin -like PCBs, and DDE in U.S. Fast Food. Chemosphere.1995;34:1449-57
  13. Stevens MF,Ebell GF,Psaila-Savona P. Organochlorine pesticides in Western Australian nur-singmothers.Med J Aust.1993;158:238-4
  14. Kutz FW, Wood PH, Bottimore DP. Organochlorine pesticides and polychlorinated biphenyls in human adiposetissue. Rev Environ Contam Tocicol.1991;120:1-82.
  15. KFDA. A notice from 2008-23. Korea Food and Drug Administration. Seoul.2008
  16. KFDA.A notice from 2008-3. Korea Food and Drug Administration. Seoul.2008.
  17. Kim HY,Lee YJ,Hong KH,KwonYK,Ko HS,Lee YK,Lee CW.Studies on the contents of naturally occuring of sulfite in foods. Korean J Food Sci Technol.200;32:544-9.
  18. Kim HJ,Kim YK,Smith M.Sulfiteanalysis by ion exclusion chromatography: Application to the food and beverage industries.Food Technol.1988;11:113-5.
  19. Holak W,Patel B. Differential pulse polarographic determination of sulfites in foods.J Assoc Off Anal Chem.1987;70:572-8.
  20. LawrenceJF,ChadhaRK.Determination of sulfite in foods by headspace liquid chromatography. J Assoc Off Anal Chem.1988;71:930-3.
  21. Perfetti GA, Joe FL, Diachenko GW. Liquid chromatographic determination of sulfite in grapesand selected grapeproducts. J Assoc Off Anal Chem.1989;72:903-6.
  22. Holak W, Specchio J. Determination of sulfites in foods by simultaneous nitrogen purging and differential pulse polarography. J Assoc Off Anal Chem. 1989;72:476-80
  23. Sullivan JJ, Hollingworth TA, Wekell MM, Newton RT, Larose JE. Determination of sulfitein food by flow injection analysis. J Assoc Off Anal Chem.1986;69:542-6.
  24. Cho JH, Kim DH, Seong RS, Oh MH, Kang IH, Shim YH, Kim EK, Cho CH, Ji SK, Lee CK, Song YS, Oh JS, Won DH, Myung SW, Kim NJ. Studies on monitoring hazardous substances of natural medicines. Annual Report of KFDA. 2000;4:567-82
  25. Kim CM, song BJ, Na HS. Determination of sulfite contents in medicinal herbs. J Korean Soc Food Sci Nutr. 2000;29:375-9.
  26. Seo CS, Huang DS, Lee JK, Ha HK, Chun JM, Um YR, Jang S, Shin HK. Concentration of heavy metals, residual pesticides and sulfur dioxide of before/after a decoction. Kor.J. Herbology.2008;23:51-8.
  27. Seo CS, Huang DS, Lee JK, Ha HK, Chun JM, Um YR, Jang S, Shin HK. Concentration of heavy metals, residual pesticides and sulfur dioxide of before/after a decoction. -Inprescription of digestive system -Kor.J.Herbology.2009 ;24:111-9.