The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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The Fruits of Crataegus pinnatifida Bunge ameliorates Learning and Memory Impairments Induced by Scopolamine

기억력 감퇴모델에서 산사의 기억력 개선 효과에 관한 연구

  • Wang, Su-Bin (Department of Herbal Medicinal Pharmacology, Daegu Haany University) ;
  • Ahn, Eun-Mi (Department of Herbal Foodceutical Science, Daegu Haany University) ;
  • Jung, Ji-Wook (Department of Herbal Medicinal Pharmacology, Daegu Haany University)
  • 왕수빈 (대구한의대학교 한약재약리학과) ;
  • 안은미 (대구한의대학교 한방식품약리학과) ;
  • 정지욱 (대구한의대학교 한약재약리학과)
  • Published : 2009.12.30
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Abstract

Objectives : In the present study, we assessed the effects of the ethanolic extract of Crataegus pinnatifida Bunge on the learning and memory impairments induced by scopolamine using the passive avoidance and the Morris water maze tasks in mice. Methods : The cognition-enhancing effect of C. pinnatifida was investigated using a passive avoidance test, the Morris water maze test and Y-maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Results : The ethanolic extract of C. pinnatifida (100, and 200 mg/kg) significantly reversed the scopolamine-induced cognitive impairments in the passive avoidance test (p < 0.05). Moreover, C. pinnatifida (200 mg/kg) also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (p < 0.05). On the Y-maze test, C. pinnatifida (100, and 200 mg/kg) also significantly reversed scopolamine- induced cognitive impairments in mice (p < 0.05). Conclusions : The ethanolic extract of Crataegus pinnatifida dramatically possesses the anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent on the learning models.

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References

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