딜티아젬 중독증 이환견에서 경피용 체외심박조절기의 적용 증례

Transcutaneous Cardiac Pacing in a Dog with Diltiazem Intoxication

  • 이승근 (고려동물병원) ;
  • 현창백 (강원대학교 수의학부(대학) 수의학과 소동물 내과교실)
  • Lee, Seung-Keun (Korea Animal Hospital) ;
  • Hyun, Chang-Baig (Section of Small Animal Internal Medicine, School of Veterinary Medicine, Kangwon National University)
  • 발행 : 2009.04.30

초록

11년령의 수컷 비글(10.5 kg)이 사고로 과량의 딜티아젬을 섭취한 후 급작스러운 서맥과 심한 저혈압으로 내원하였다. 환자는 경피용 체외 심박조절기의 적용하에서 등장성 crystalloid 용액, 아트로핀, calcium gluconate, 도부타민, 글루카곤, 위세척의 처치를 받았다. 단기간의 경피용 체외심박조절기의 사용과 약물적 치료요법으로 환자의 심장 리듬과 상태는 안정화 되었다.

An 11-year-old male Beagle, weighing 10.5 kg, was presented with sudden bradyarrhthmia and severe hypotension after incidental ingestion of diltiazem. The dog was treated with intravenous(IV) isotonic crystalloid solution, atropine, calcium gluconate, dobutamine, glucagon and gastric lavage under the aid of temporary transcutaneous cardiac pacing. With the short-term use of transcutaneous cardiac pacing and medical treatment, the heart rhythm and the condition of the patient were stabilized.

키워드

참고문헌

  1. Cooke KL, Snyder PS. Calcium channel blockers in veterinary medicine. J Vet Intern Med 1998; 12: 123–131 https://doi.org/10.1111/j.1939-1676.1998.tb02107.x
  2. TC, Hansen BD, Atkins CE, Sidley JA, Keene BW. Noninvasive transthoracic temporary cardiac pacing in dogs. J Vet Intern Med 2003; 17: 663-667 https://doi.org/10.1111/j.1939-1676.2003.tb02497.x
  3. Gelzer AR, Kraus MS. Management of atrial fibrillation. Vet Clin North Am Small Anim Pract 2004; 34: 1127–1144 https://doi.org/10.1016/j.cvsm.2004.05.001
  4. Holder T. Calcium channel blocker toxicosis. Vet Med 2000; 95: 912–915
  5. Hussain MD, Tam YK, Finegan BA, Coutts RT. Simple and sensitive high-performance liquid chromatographic method for the determination of diltiazem and six of its metabolites in human plasma. J Chromatogr 1992; 582: 203–209 https://doi.org/10.1016/0378-4347(92)80320-P
  6. Isbister GK. Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intravenous calcium. Emerg Med J 2002; 19: 355–357 https://doi.org/10.1136/emj.19.4.355
  7. Kittleson MD, Kienle RD. Drug used in treatment of cardiac arrhythmia. In: Small Animal Cardiovascular Medicine. St. Louis: Mosby, 1998: 502-524
  8. Lee S, Hyun C. Evaluation of changes in cardiac biomarkers and serum enzymes after short (1 hr) and long-duration (3 hr) transcutaneous cardiac pacing. Am J Vet Res 2008; in press
  9. Niemann JT, Rosborough JP, Garner D. External noninvasive cardiac pacing: a comparative hemodynamic study of two techniques with conventional endocardial pacing. Pacing Clin Electrophysiol 1984; 7: 230-236 https://doi.org/10.1111/j.1540-8159.1984.tb04890.x
  10. Plumb DC. Plumb's Veterinary Drug Handbook, London: Blackwell Publishers, 2005; 369-371
  11. Proano L, Chiang WK, Wang RY. Calcium channel blocker overdose. Am J Emerg Med 1995; 13: 444–450 https://doi.org/10.1016/0735-6757(95)90137-X
  12. Ramoska EA, Spiller HA, Winter M, Borys D. A one-year evaluation of calcium channel blocker overdoses: toxicity and treatment. Ann Emerg Med 1993; 22: 196–200 https://doi.org/10.1016/S0196-0644(05)80202-1
  13. Roberts D, Honcharik N, Sitar DS, Tenenbein M. Diltiazem overdose: pharmacokinetics of diltiazem and its metabolites and effect of multiple dose charcoal therapy. J Toxicol Clin Toxicol 1991; 29: 45–52 https://doi.org/10.3109/15563659109038596
  14. Romano G, Barbera N, Rossitto C, Spadaro G. Lethal diltiazem poisoning. J Anal Toxicol 2002; 26: 374–377 https://doi.org/10.1093/jat/26.6.374
  15. Schoffstall JM, Spivey WH, Gambone LM, Shaw RP, Sit SP. Effects of calcium channel blocker overdose-induced toxicity in the conscious dog. Ann Emerg Med 1991; 20: 1104–1108 https://doi.org/10.1016/S0196-0644(05)81384-8
  16. Syring RS, Costello MF, Poppenga RH. Calcium channel blocker toxicity. J Vet Emerg Crit Care. 2008; 18: 75-80 https://doi.org/10.1111/j.1476-4431.2007.00269.x
  17. Syverud SA, Dalsey WC, Hedges JR. Transcutaneous cardiac pacing: determination of myocardial injury in a canine model. Ann Emerg Med 1983; 12: 745–748 https://doi.org/10.1016/S0196-0644(83)80249-2
  18. Zoll PM, Belgard AH, Weintraub MJ, Frank HA. External mechanical cardiac stimulation. N Engl J Med 1976; 294: 1274-1275 https://doi.org/10.1056/NEJM197606032942307