Journal of Environmental Science International (한국환경과학회지)

The Korean Environmental Sciences Society (한국환경과학회)
권호 표지
DOI QR코드

DOI QR Code

The Occurrences of Pharmaceutical and Personal Care Products (PPCPs) in Mankyung River, South Korea

만경강 수중에서 신체보초제품(PPCPS)의 잔류

  • Kim, Joon-Woo (Environmental and Symbiotic Sciences, Prefectural University of Kumamoto) ;
  • Kim, Jong-Gu (Faculty of Civil & Environmental Engineering, Kunsan National University) ;
  • Jang, Hyo-Sang (Faculty of Civil & Environmental Engineering, Kunsan National University) ;
  • Cho, Hyeon-Seo (Faculty of Marine Technology, College of Fisheries & Ocean Science, Chonnam National University) ;
  • Takao, Yuji (Faculty of Environmental Studies, Nagasaki University) ;
  • Arizono, Koji (Environmental and Symbiotic Sciences, Prefectural University of Kumamoto)
  • Published : 2009.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

In recent years, environmental pollution by phannaceuticals and personal care products (PPCPs) in the aquatic environment is of great concern worldwide. Recent studies have been reported to occur in a variety of environmental organisms such as surface, drinking and ground water, soils, sediments and hospitals. The purpose of this study was to evaluate the occurrence and environmental behavior of fourteen human PPCPs in surface waters of Mankyung River in South Korea. We were conducted to field survey for water quality and PPCPs analysis at November, 2006. PPCPs were analyzed by liquid chromatograph coupled with a tandem mass spectrometer (HPLC-MS/MS). The concentration of COD was measured to be 2.37$\sim$19.71 mg/L, which was belong to 4$\sim$5 grade in water quality criteria of lake. Station 2 that there is no pollution in upper stream, was appeared to lower concentration. The concentration of TN and TP, that is cause matter of eutrophication, were found to be 7.78$\sim$35.42 mg/L and 0.08$\sim$0.95 mg/L, respectively, which were exceeding 5 grade in Lake water quality criteria. The 11 kind of PPCPs compounds except levofloxacin and triclosan were detected to Mankyung river. PPCPs concentrations of STP(Sewer Treatment Plant) effluents and aquatic environment in Mankyung river have been detected in the range from dozens of ng/L to hundreds of ${\mu}g/L$ that by order of atenolol, carbamazepine, propranolol, Ibuprofen, erythromycin, ifenprodil, clarithromycin, mefenamic acid, fluconazole, indomethacin, disopyramide. PPCPs concentration of Station 1 and 5, which was influenced by Jeonju STP and Wanju STP, was detected high values. Station 2 that there is no pollution, showed lower values. Station 3 which joined Gosan stream and Jeonju stream and station 4 which influenced by stock wastewater was detected to low values.

Keywords

References

  1. Furlong D. N., Aston J. R., 1982, Adsorption of polyoxyethylated nonyl phenols at silica/aqueous solution interfaces, Colloids and Surfaces, 4(2), 121-129 https://doi.org/10.1016/0166-6622(82)80002-4
  2. Odum J., Lefevre P. A., Tittensor S., Paton D., Routledge E. J., Beresford N. A., Sumpter J. P., Ashby J., 1997, The rodent uterotrophic assay: Critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay, Regulatory Toxicology and Pharmacology, 25(2), 176-188 https://doi.org/10.1006/rtph.1997.1100
  3. Mandich A., Bottero S., Benfenati E., Cevasco A., Erratico C., Maggioni S., Massari A., Pedemonte F., Vigano L., 2007, In vivo exposure of carp to graded concentrations of bisphenol A, General and Comparative Endocrinology, 153(1-3), 15-24 https://doi.org/10.1016/j.ygcen.2007.01.004
  4. Bredhult C., Backlin B. M., Olovsson M., 2007, Effects of some endocrine disruptors on the proliferation and viability of human endometrial endothelial cells in vitro, Reproductive Toxicology, 23(4), 550-559 https://doi.org/10.1016/j.reprotox.2007.03.006
  5. Kolpin D. W., Furlong E. T., Meyer M. T., Thurman E. M., Zaugg S. D., Barber L. B., Buxton H. T., 2002, Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance, Environ. Sci. Technol., 36, 1202-1211 https://doi.org/10.1021/es011055j
  6. Tixier C., Singer H. P., Oellers S., Muller S. R., 2003, Occurrence and fate of Carbamazepine, clofibric acid, diclofenac, Ibuprofen, ketoprofen, and naproxen in surface waters, Environ. Sci. Technol., 37, 1061- 1068 https://doi.org/10.1021/es025834r
  7. Ashton D., Hilton M., Thomas K. V., 2004, Investigating the environmental transport of human pharmaceuticals to streams in the United Kingdom, Sci. Total Environ., 333, 167-184 https://doi.org/10.1016/j.scitotenv.2004.04.062
  8. Ternes T. A., Bonerz M., Herrmann N., Teiser B., Andersen H. R., 2007, Irrigation of treated watewater in Braunschweig, Germany: An option to remove pharmaceuticals and musk fragrances, Chemosphere, 66, 894-904 https://doi.org/10.1016/j.chemosphere.2006.06.035
  9. 환경부, 1998, 수질오염공정시험법.
  10. Kim S. D., Cho J., Kim I. S., Vanderford B. J., Snyder S. A., 2007, Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters, Water Res., 1013-1021
  11. Buser H. R., Poiger T., Muller M. D., 1999, Occurrence and environmental behavior of the chiral pharmaceutical drug Ibuprofen in surface waters and in wastewater, Environ. Sci. Techol., 33(15), 2529- 2535 https://doi.org/10.1021/es981014w
  12. Zuccato E., Castiglioni S., Fanelli R., 2005, Identification of the pharmaceuticals for human use contamination the Italian aquatic environment, Journal of Hazardous Materials, 122, 205-209 https://doi.org/10.1016/j.jhazmat.2005.03.001
  13. Arizono K, Takao Y., 2006, The environmental pollution of pharmaceuticals and its ecotoxicological impacts., J. Japan Soci. Water Environ., 29(4), 16-20
  14. 岩根泰藏, 2003, 水還境中の医藥品化學物質, 國立環境硏究所ニュ一ス, 22(4)
  15. Logan R. F., Little J., Hawtin P. G., Hardcastle J. D., 1993, Effect of aspirin and non-steroidal anti-inflanunatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme, BMJ., 307, 285-289 https://doi.org/10.1136/bmj.307.6899.285
  16. Moldovan Z., 2006, Occurrences of pharmaceutical and personal care products as micropollutants in rivers from Romania, Chemo., 64(11), 1808-1817 https://doi.org/10.1016/j.chemosphere.2006.02.003
  17. Daughton G. G., Ternes T. A., 1999, Pharmaceuticals and personal care products in the environment: agents of subtle change, Environ. Health Perspect., 107(6), 907-938 https://doi.org/10.2307/3434573
  18. Wiegel S., Aulinger A., Brockmeyer R., Harms H., Lomer J., Reincke H., Schmidt R., Stachel B., Tumpling W., Wanke A., 2004, Pharmaceuticals in the river Elbe and its tributaries, Chemo., 57, 107- 126 https://doi.org/10.1016/j.chemosphere.2004.05.017
  19. Ternes T. A., 1998, Occurrence of drugs in German sewage treatment plants and rivers, Water Res., 32(11), 3245-3260 https://doi.org/10.1016/S0043-1354(98)00099-2
  20. Donger V. G., Karmuse P. P., Ghugre P. D., Salunke S. M., Panda N., Kumar A., 2006, Preparative isolation and structural elucidation of impurities in fluco nazole by LCIMS/MS, J. Phannaceutical and Biomedical Analysis, 42, 334-340 https://doi.org/10.1016/j.jpba.2006.04.012
  21. Kilic B., Kruse M., Stahlmann R., 2006, The in vitro effects of quinupristin/dalfopristin, erythromycin and levofloxacin at low concentrations of the expression of different cell adhesion molecules on the surface of endothelial cells (Eahy926), Toxicol., 218, 30-38 https://doi.org/10.1016/j.tox.2005.09.014
  22. Tatarazako N., Ishibashi H., Teshima K., Kishi K., Arizono K., 2004, Effects of triclosan on various aquatic organisms, Environ. Sci., 11(2), l33-140
  23. Thomas P. M., Foster G. D., 2005, Tracking acidic pharmaceuticals, caffeine, and triclosan through the wastewater treatment process, Environ. Toxicol. Chem., 24(1), 25-30 https://doi.org/10.1897/04-144R.1