대한한의학회지 (The Journal of Korean Medicine)

  • 제30권2호
  • /
  • Pages.133-144
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  • 2009
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  • 1010-0695(pISSN)
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  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

선방활명음(仙方活命飮)이 알레르기 비염을 동반한 급성 비부비동염 마우스에 미치는 영향

The Effects of Sunbanghwalmyung-eum Extract on Acute Sinusitis-induced Mouse

  • 박민철 (동국대학교 한의과대학 안이비인후피부과학교실) ;
  • 홍승욱 (동국대학교 한의과대학 안이비인후피부과학교실)
  • Park, Min-Chul (Dept. of Oriental Medical Ophthalmology, Otolaryngology & Dermatology, College of Oriental Medicine, Dongguk University) ;
  • Hong, Seung-Ug (Dept. of Oriental Medical Ophthalmology, Otolaryngology & Dermatology, College of Oriental Medicine, Dongguk University)
  • 발행 : 2009.03.31
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초록

Background and Objectives: Sinusitis, referring to an inflammatory disease that occurs on the mucus membrane inside the sinus, is one of the most common diseases in the otorhinolaryngology area. In oriental clinic, Sunbanghwalmyungeum (SHE) has been used as a primary prescription to treat inflammatory diseases and intumescence and to treat sinusitis. The aim of this study was to investigate the anti-inflammatory and anti-allergic effects of SHE on acute sinusitis induced mice. Materials and Methods: BALB/c mice were divided into three groups: the normal group, the group inoculated with S. pneumoniae which caused them allergic rhinitis (control group), and the group treated with the SHE extract after it was treated the same as the control group (sample group). We investigated the inhibition of Th 2 cell differentiation by SHE and the suppression of NF-${\kappa}B$ activation. Results: NF-${\kappa}B$ activation was suppressed, and iNOS & COX-2 production were inhibited by SHE in acute sinusitis. IL-4 and STAT 6 also appeared to be suppressed. The number of eosinophils in the sample group noticeably decreased when compared to the control group. In the general morphologic change, the increase of damaged respiratory ciliated epithelium & eosinophil's infiltration were decreased in the sample group. Goblet cells were maintained in the sample group. MIP-2 and HSP-70 decreased in the sample group. Apocrine secretion decreased in the sample group. Conclusion: The results suggest that SHE is significantly effective in the treatment of inflammation caused by acute sinusitis through the suppression of NF-${\kappa}B$ activation and the inhibition of Th 2 cell differentiation.

키워드

참고문헌

  1. 이기영, 김규언. 최신 알레르기의 진료. 서울:한국의학사. 2001:571-8.
  2. 민양기. 임상비과학, 서울:일조각, 1997:281-378
  3. 채병윤. 동의안이비인후과학. 서울:집문당. 1994 :332.
  4. 노석선. 원색안이비인후과학. 서울:일중사. 1999 :73-79.
  5. 장마합주 황제내경. 서울:고문사 1974: 101, 257.
  6. 이인수 만성부비동염 환자의 임상적 고찰. 한방 안이비인후피부과학회지. 2004;17(3): 102-106.
  7. 이규진, 구영희. 성인부비동염의 재발율에 대한 임상적 고찰. 대한한의학회지. 2006; 27(3): 237 -250.
  8. 김중호, 김윤범, 채병윤. 비연질환(부비동질환) 의 한방치험 12례. 대한한의학회지. 1994; 15(2) :113-121.
  9. 김중호, 채병윤. 비연질환에 대한 임상례. 대한한의학회지. 1989; 10(2) : 180-186.
  10. 채병윤. 비연질환의 치료에 관한 임상적 연구. 대한한의학회지. 1985;6(1):93-103.
  11. 황우석, 이재성, 최중용, 정희재, 이형구, 정승기. 소청룡탕으로 호전된 천식을 동반하는 만성부비 동염 2례. 대한한의학회지. 2003;24(1): 207-212.
  12. 陳自明. 婦人良h佼注補遺. 上海:上海和|早技術 出版社. 1991:637.
  13. 이범용, 안덕균, 우은란, 박호군. 선방활명음의 항균효능 및 성분에 관한 연구. 대한한의학회지. 1998; 19(1 ):89-99.
  14. 최인화, 채병윤. 선방활명음의 항암 및 면역반응에 관한 실험적 연구. 경희대논문집: 1992;15: 341-359.
  15. 안현주, 지선영. 선방활명음 및 구성약물의 세포 독성에 관한 실험적 연구. 한방안이비인후피부 과학회지. 2004;17(1):131-142.
  16. 조수현, 천승철, 임진호, 이상곤, 지선영. 선방활 명음의 중이염 치험례. 한방안이비인후피부과학회지. 2003;16(1):198-205.
  17. 민양기. 일차진료를 위한 이비인후과학입상. 서울:일조각 2000:98-109
  18. Drettner B, Lindholm C-E. The borderline between acute rhinitis and sinusitis. Acta Otoloaryngol(stockh). 1967;64:508-513. https://doi.org/10.3109/00016486709139136
  19. 해리슨내과학편찬위원회. 내과학. 서울:정담.1997 :550-551.
  20. 이철희, 이재서. 알레르기와 부비동염. 알레르기. 1994;14(2):163-174.
  21. Su W-Y, Liu C, Hung S-Y et al. Bacteriologic study in chronic maxillary sinusitis. Laryngoscope. 1983;93:931-934.
  22. Brook I. Bacteriology of chronic maxillary sinusitis in adults. Ann Otal Rhinol Laryngol. 1989;98:426-428.
  23. Savolainen S. Allergy in patients with acute maxillary sinusitis. Allergy. 1989;44:116-122. https://doi.org/10.1111/j.1398-9995.1989.tb02234.x
  24. De Cleyn KM, Kersschot EA, DeClerck LS, Ortmanns PM, De Schepper AM, Van Bever HP, Stevens WJ. Paranasal sinus pathology in allergic and non-allergic respiratory tract disease. Allergy. 1986;41:313-318. https://doi.org/10.1111/j.1398-9995.1986.tb00306.x
  25. 이상문. Mouse cell에서 탁리소독음의 항산화작 용과 항염증효과. 한방안이비인후피부과학회지. 2007;20(3):43-50.
  26. 李挺. 編注醫學入門. 서울:의성당. 1994:756-758.
  27. 허준. 동의보감III 제3판. 서울:대성문화사. 1999: 375-376.
  28. Bomer K, Briclita A, Baroody F, Boonlayangoor S, Li X, Naclerio RM. A mouse model of acute bacterial rhinosinusitis. Arch Otolaryngol Head Neck Surg. 1998;124:1227-1232.
  29. 안병훈, 박연호, 김동은, 송인혁, 남여진, 남성일, 김상표, 류남희. 폐렴연구균을 이용한 생쥐에서의 만성 비부비동염 실험모델. Korean J Otolaryngol. 2006;49:52-59.
  30. Gonzalez M. F., Shiraishi K., Hisanaga K., Sagar S. M., Mandabach M., Sharp F. R. Heat shock protein as markers of neuronal injury. Mol. Brain Res. 1989;6: 93-100. https://doi.org/10.1016/0169-328X(89)90033-8
  31. Vass K., Beger M. L., Nowak T. S., Jr Lassmann H. Induction of stress protein HSP70 in nerve cell after status epilepticus in the rat. Neurosci Lett. 1989;100: 259-264. https://doi.org/10.1016/0304-3940(89)90695-2
  32. Bergstedt K., Hu B. R., Weiloch T. Initiation of protein synthesis and heat shock protein-72 expression in the rat brain following severe insulin induced hypoglycemia. Acta Neuropathol. 1989;86: 259-264. https://doi.org/10.1007/BF00304140
  33. Baeuerle P. A. IkB-NF-kB structure: at the interface of inflammation control. Cell. 1998;95:729-731. https://doi.org/10.1016/S0092-8674(00)81694-3
  34. Takeno S, Hirakawa K, Ueda T, Furukido K, Osada R, Yajin K. Nuclear factor-kappa B activation in the nasal polyp epithelium: relationship to local cytokine gene expression. Laryngoscope.2002; 112(1): 53-58. https://doi.org/10.1097/00005537-200201000-00010
  35. Moncada S., Palmer, R. M., Higgs E. A. Nitric oxide:physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 1991;43:109-142.
  36. Jeon SY, Kim JP, Kim EA, Ahn SK, Kim BG. Rat model of platelet-activating factor-induced rhinosinusitis. Ann Otol Rhinol Laryngol. 2005; 114(5): 393-398.
  37. Demoly P, Crampette L, Lebel B, Campbell AM, Mondain M, Bousquet J. Expression of cyclooxygenase 1 and 2 proteins in upper respiratory mucosa. Clin Exp Allergy. 1998;28(3):278-283. https://doi.org/10.1046/j.1365-2222.1998.00212.x
  38. Gosepath J, Brieger J, Mann WJ. New immunohistologic findings on the differential role of cyclooxygenase 1 and cyclooxygenase 2 in nasal polyposis. Am J Rhinol. 2005;19(2): 111-116.
  39. Borich L. Allergic rhinitis: Systemic inflammation and implications for management. J Allergy Clin Immunol. 2002:60-62.
  40. Yang SH, Hong CY, Yu CL. Decreased serum IgE level, decreased IFN-γ and IL-5 but increased IL-10 production, and suppresed cyclooxygenase 2 mRNA expression in patients with perennial allergic rhinitis after treatment with a new mixed formula of Chinese herbs. Int Immunopharmacol. 2001;1(6):1173-1182. https://doi.org/10.1016/S1567-5769(01)00051-0
  41. Chrousos GP. Stress, chronic inflammation, and emotional and physical well-being: Concurrent effects and chronic sequelae. J Allergy Clin Immunol 2000;106:S275-291. https://doi.org/10.1067/mai.2000.110163
  42. Koreck AI, Csoma Z, Bodai L, Ignacz F, Kenderessy AS, Kadocsa E, Szabo G, BorZ, Erdei A, Szony B, Homey B, Dobozy A, Kemedy L. Rhinophototherapy: A new therapeutic tool for the management of allergic rhinitis. J Allergy Clin Immunol. 2005;115:541-547. https://doi.org/10.1016/j.jaci.2004.11.005
  43. 이충은 : JAK-STAT pathway를 경유하는 cytokine 과 호르몬의 작용기전. 대한내분비학회. 2000;15 (3):367-387.