대한한의학회지 (The Journal of Korean Medicine)

  • 제30권2호
  • /
  • Pages.117-126
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  • 2009
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  • 1010-0695(pISSN)
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  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

도인(桃仁)의 중대뇌동맥 폐색 유발 흰쥐에서 신경보호 효과

Neuroprotective Effect of Semen Persicae in Middle Cerebral Artery Occlusion Rats

  • 송미영 (동국대학교 한의과대학 재활의학과학교실) ;
  • 김호준 (동국대학교 한의과대학 재활의학과학교실) ;
  • 이명종 (동국대학교 한의과대학 재활의학과학교실)
  • Song, Mi-Young (Dept. of Rehabilitaion Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim, Ho-Jun (Dept. of Rehabilitaion Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee, Myeong-Jong (Dept. of Rehabilitaion Medicine, College of Oriental Medicine, Dongguk University)
  • 발행 : 2009.03.31
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초록

Objectives: This study was performed to investigate the effects of Semen Persicae (SP) on infarct volume, COX-2 protein expression in the middle cerebral artery occlusion (MCAo) rats. Methods: Twenty-eight rats were randomly assigned to four groups (MCAo experimental group, MCAo control group, sham experimental group, control group). The middle cerebral artery (MCA) was occluded in the MCAo group by proximal focal cerebral ischemia rat model, while the MCA was not occluded in the sham group. SP extraction was administrated for 4 days to each experimental group. Neuroprotective effects were investigated by measurement of brain damage using 2, 3, 5-triphenyltetrazolium chloride staining and analysis of COX-2 protein expression by western blotting. Results: The occurrence of infarct volume in the SP oral administration group decreased compared to the control group. COX-2 protein expression in the SP oral administration group decreased compared to the control group. Conclusions: The present study demonstrates the effect of SP in reducing infarct volume and decreasing COX-2 expression.

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