Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
권호 표지

Diallyl Disulfide (DADS) Induces Upregulation of PTEN in Human Leukemia Cells

  • Chung, Weon-Kuu (Department of Radiation Oncology, Konyang University Medical School) ;
  • Lee, Byoung-Kil (Department of Radiation Oncology, Konyang University Medical School) ;
  • Lee, Young-Rae (Department of Radiation Oncology, Chonbuk National University Medical School) ;
  • Park, Jin-Ny (Division of Hematology/Oncology, Gachon University Medical Center) ;
  • Kwon, Hyoung-Chul (Department of Radiation Oncology, Chonbuk National University Medical School)
  • 정원규 (건양의대 방사선 종양학과) ;
  • 이병길 (건양의대 방사선 종양학과) ;
  • 이영래 (전북 의대 방사선 종양학과) ;
  • 박진희 (가천의대 혈액종양내과) ;
  • 권형철 (전북 의대 방사선 종양학과)
  • Published : 2009.03.31
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Abstract

The differentiation of leukemia cells into mature cells is a major target of the human leukemia therapy. As differentiated leukemia cells lose their proliferative and tumor-forming abilities, differentiation inducers may be useful for the treatment of leukemia. In this study, the experiments were designed to determine whether diallyl disulfide (DADS) regulates expressions of tumor suppressor protein PTEN (phosphatase and tension homologue) in HL60 cells. DADS causes upregulation of PTEN in a time- and dose-dependent manner, which was correlated with decrease of phospho-Akt level. These results suggest that DADS induces upregulation of PTEN in human leukemia cells. These results suggest that DADS may be a useful anticancer agent for management of human leukemia.

Keywords

References

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