Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Neuroprotective Effects of Some Plant Extracts Against Dopamine-induced Oxidative Stress on Neuronal Cell

Dopamine에 의해 산화적 스트레스를 받은 Neuronal Cell에 뇌 보호 효과를 가지는 수종 생약추출물의 검색

  • Koo, Uk (Natural Product Research Institute, College of Pharmacy, Seoul National University) ;
  • Lee, Hak-Ju (Korea Forest Research Institute) ;
  • Lee, Dong-Ho (College of Life sciences & Biotechnology, Korea University) ;
  • Lee, Hyun-Jung (Korea Forest Research Institute) ;
  • Ham, Ah-Rom (Natural Product Research Institute, College of Pharmacy, Seoul National University) ;
  • Mar, Woong-Chon (Natural Product Research Institute, College of Pharmacy, Seoul National University)
  • 구억 (서울대학교 약학대학 천연물과학연구소) ;
  • 이학주 (국립산림과학원) ;
  • 이동호 (고려대학교 생명과학대학) ;
  • 이현정 (국립산림과학원) ;
  • 함아롬 (서울대학교 약학대학 천연물과학연구소) ;
  • 마응천 (서울대학교 약학대학 천연물과학연구소)
  • Published : 2009.03.31
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Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzhemier's disease. Neuropathologically, PD is characterized by the selective loss of dopaminergic neurons. The neuronal toxicity of cytosolic excess dopamine (DA) has been described in many studies using several cell lines. In dopaminergic neurons, cytosolic excess DA is easily oxidized via monoamine oxidase (MAO)-B, tyrosinase or by auto-oxidation to produce neurotoxic metabolites such as DA quinone. So, in the present study, we induced cell death by treatment of DA ($600{\mu}M$) in human neuroblastoma SH-SY5Y cell which was treated samples before 24 hr, and cell viability was measured by fluorescence activated cell sorter (FACs) analysis. Of those tested, the extracts of Poria cocos (赤茯笭)(whole), Gastrodia elata (rhizomes), Eucommia ulmoides (炒)(barks), Syneilesis palmata (whole), Acorus gramineus (rhizomes), Ligustrum japonicum (leaves) showed neuroprotective effects in dose dependent manner.

Keywords

References

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