Korean Journal of Environmental Agriculture (한국환경농학회지)

The Korean Society of Environmental Agriculture (한국환경농학회)
권호 표지
DOI QR코드

DOI QR Code

Bioconcentration of Pirimiphos-methyl in Killifish (Oryzias latipes)

  • Seo, Jong-Su (Analytical Research Center, Korea Institute of Toxicology) ;
  • Chang, Hee-Ra (Analytical Research Center, Korea Institute of Toxicology) ;
  • Hamer, Mick (Syngenta, Jealott's Hill International Research Centre) ;
  • Kim, Kyun (Analytical Research Center, Korea Institute of Toxicology)
  • Published : 2009.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Killifish (Oryzias latipes) were exposed to an organophosphate pesticide, pirimiphos-methyl, in a flow-through system to determine the bioconcentration factor (BCF) following GLP (Good Laboratory Practice). This study was conducted at two different concentrations (1 and $10\;{\mu}$g/L) of $^{14}C$-labeled pirimiphos-methyl for 28 days uptake and 14 days depuration according to the OECD 305 test guideline. The $BCF_{ss}$ for total radioactive residues in whole fish were 1,251 and 1,277 for low and high concentrations, respectively. The $BCF_k$ based on the uptake and depuration rate constants were 1,200 for both low and high concentrations. During the depuration phase, the accumulated test substance was rapidly depurated from fish. Greater than 95% of the residue at steady-state was depurated after 2 days. Although the measured BCF values were high, pirimiphos-methyl could be evaluated as a low risk from bioaccumulation by aquatic organisms due to the short depuration period and low amount of bound residue (1.5%). We suggest that in evaluating bioaccumulation, not only the BCF should be considered, but also depuration time and bound residue in aquatic organisms give an indication of the potential environmental risks.

Keywords

References

  1. Barron, M. G. (1990) Bioconcentration. Environ. Sci. Toxicol. 24, 1612-1618
  2. OECD (1996) OECD guidelines for testing of chemicals, Proposal for updating guideline 305, Bioconcentration: Flow-through fish test, 14 June 1996, Paris
  3. Dimitrov, S. D., Dimitrova, N. C., Walker, J. D., Veith, G. D. and Mekenyan, O. G. (2002) Predicting bioconcentration factors of highly hydrophobic chemicals. Effects of molecular size. Pure Appl. Chem. 74, 1823- 1830 https://doi.org/10.1351/pac200274101823
  4. Nordberg, A. and Ruden, C. (2007) The usefulness of the bioconcentration factors as a tool for priority setting in chemicals control. Toxicol. Lett. 168, 113- 120 https://doi.org/10.1016/j.toxlet.2006.11.004
  5. Renberg, L., Tarkpea, M. and Sundstrom, G. (1986) The use of the bivalve Mytilus edulis as a test organism for bioconcentration studies II. The bioconcentration of two $^{14}C$-labelled chlorinated paraffins. Ecotoxicol. Environ. Safety 11, 361-372 https://doi.org/10.1016/0147-6513(86)90109-0
  6. Seo, J. S., Liu, K. H., Chung, K. H., Shin, J. S. and Kim, J. H. (2002) Bioconcentration and depuration of pyribenzoxim in Common Carp (Cyprinus carpio). Bull. Environ. Contam. Toxicol. 68, 617-622 https://doi.org/10.1007/s001280299
  7. Jimenez, B. D., Cirmo, C. P. and McCarthy, J. F. (1987) Effects of feeding and temperature on uptake, elimination and metabolism of benzo[a]pyrene in the bluegill sunfish (Lepomis macrochirus). Aquat. Toxicol. 10, 41-57 https://doi.org/10.1016/0166-445X(87)90026-9
  8. Hou, X., Shen, J., Zhang, S., Jiang, H. and Coats, J. R. (2003) Bioconcentration and elimination of sulfamethazine and its main metabolite in Sturgeon (Acipenser schrenkii). J. Agric. Food Chem. 51, 7725-7729 https://doi.org/10.1021/jf030492+
  9. Devillers, J., Bintein, S. and Domine, D. (1996) Comparison of BCF models based on log P. Chemosphere 33, 1047-1065 https://doi.org/10.1016/0045-6535(96)00246-9
  10. Lu, X., Tao, S., Cao., J. and Dawson, R. W. (1999) Prediction of fish bioconcentration factors of nonpolar organic pollutants based on molecular connectivity indices. Chemosphere 39, 987-999 https://doi.org/10.1016/S0045-6535(99)00020-X
  11. Meylan, W. M., Howard, P. H., Boethling, R. S., Aronson, D., Printup, H. and Gouchie, S. (1999) Improved method for estimating bioconcentration/ bioaccumulation factor from octanol/water partition coefficient. Environ. Toxicol. Chem. 18, 664-672 https://doi.org/10.1002/etc.5620180412
  12. Verhaar, H. J. M., DeJongh, J. and Hermens, J. L. M. (1999) Modeling the bioconcentration of organic compounds by fish: A novel approach, Environ. Sci. Technol. 33, 4069-4072 https://doi.org/10.1021/es980709u
  13. Council of the European Union (2007) Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restrictions of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council. 29 October 2007, Brussels
  14. Tomlin, C. D. S. (2006) The Pesticide Manual (14th), British Crop Protection Council, UK, p.849-850.
  15. U.S. EPA. (2003) Pirimiphos-methyl IRED facts; http:// www.epa.gov/oppsrrd1/REDs/factsheets/pirimip hosmethyl_ired_fs.htm
  16. National Institute of Environmental Research (2006) Testing Guidelines for Toxicology Studies and in compliance with TCCA-Good Laboratory Practice Standards and Test Guidelines: Bioaccumulation Test Method. Notification No. 2006-29, Korea
  17. Honeycutt, M.E., McFarland, V.A. and McCant, D.D. (1995) Comparison of three lipid extraction methods for fish, Bull. Environ. Contam. Toxicol. 55, 469-472
  18. Franke, C., Studinger, G., Berger, G., Bohling, S., Bruckmann, U., Cohors-Fresenborg, D. and Johncke, U. (1994) The assessment of bioaccumulation, Chemosphere 29, 1501-1514 https://doi.org/10.1016/0045-6535(94)90281-X

Cited by

  1. Accumulation of current-use pesticides, cholinesterase inhibition and reduced body condition in juvenile one-sided livebearer fish ( Jenynsia multidentata) from the agricultural Pampa region of Argentina vol.185, 2017, https://doi.org/10.1016/j.chemosphere.2017.06.129