Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Antioxidant and Aldo-keto Reductase Family 1 B10 Inhibition Activities of Korean Local Plant Extracts

한국 자생식물 추출물의 항산화 및 Aldo-keto Reductase Family 1 B10 효소 억제 효과

  • Pan, Cheol-Ho (Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute) ;
  • Lee, Joo-Young (Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute) ;
  • Song, Dae-Geun (Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute) ;
  • Kim, Jong-Hwan (Specialty Crops Experiment Station, Gangwondo Agricultural Research and Extension Services) ;
  • Ahn, Soo-Young (Specialty Crops Experiment Station, Gangwondo Agricultural Research and Extension Services) ;
  • Bae, Deok-Sung (Department of Biology Education, College of Education, Chungbuk National University) ;
  • Kim, Young-Hoon (Department of Biology Education, College of Education, Chungbuk National University) ;
  • Lee, Jae-Kwon (Department of Biology Education, College of Education, Chungbuk National University)
  • 판철호 (한국과학기술연구원 강릉분원 천연물소재연구센터) ;
  • 이주영 (한국과학기술연구원 강릉분원 천연물소재연구센터) ;
  • 송대근 (한국과학기술연구원 강릉분원 천연물소재연구센터) ;
  • 김종환 (강원도 농업기술원 특화작물시험장) ;
  • 안수용 (강원도 농업기술원 특화작물시험장) ;
  • 배덕성 (충북대학교 사범대학 생물교육과) ;
  • 김영훈 (충북대학교 사범대학 생물교육과) ;
  • 이재권 (충북대학교 사범대학 생물교육과)
  • Published : 2009.12.31
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Abstract

Aldo-keto reductase family 1 B10 (AKR1B10) has been considered as a potential cancer therapeutic target. Ethanol extracts prepared from 82 Korean local plants were examined for their antioxidant activity and inhibitory effects on recombinant human AKR1B10 (rhAKR1B10) in vitro. 21 extracts showed more than 80% of ABTS radical scavenging activity at $100\;{\mu}g/mL$ and 11 extracts inhibited more than 50% of rhAKR1B10 activity at $10\;{\mu}g/mL$. Especially, 9 extracts showed potent inhibition on rhAKR1B10 activity compared with positive control tetramethylene glutaric acid.

Keywords

References

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