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Suppression Effect of Curcuma longa Rhizome-Derived Components against Nitric Oxide Synthase

  • Lee, Hoi-Seon (Department of Bioenvironmental Chemistry, College of Agriculture & Life Science, Chonbuk National University)
  • Published : 2009.12.31

Abstract

The inhibitory effects of Curcuma longa rhizome-derived materials against nitric oxide (NO) production were assessed. The inhibitory effect (57%) on NO production was evidenced by the methanol extract of C. longa at $1\;{\mu}g/mL$. In the fractionation of the methanol extract, the ethyl acetate fraction evidenced an inhibitory effect greater than 62.1% at $1\;{\mu}g/mL$. The active constituent was identified as curcumin. Curcumin exerted potent inhibitory effects of 78.7 and 65.7% at concentrations of 1 and $0.5\;{\mu}g/mL$, respectively. Furthermore, the inhibitory effect of ar-turmerone was measured as 31.3 and 15.8% at 1 and $0.5\;{\mu}g/mL$, respectively. The iNOS expression-suppressive effects of curcumin were assessed via western blot analysis. Our results suggest that curcumin and ar-turmerone may prove useful in the development of new types of NO inhibitors.

Keywords

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Cited by

  1. vol.57, pp.7, 2017, https://doi.org/10.1080/10408398.2016.1176554