Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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The Effect of Acupuncture on Methamphetamineinduced Locomotor Activity and C-Fos Expression in Rat Brain

흰쥐의 급성 메스암페타민 투여에 대한 침(鍼)의 효과

  • Choi, Seong-Hun (Dept. of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University) ;
  • Lee, Bong-Hyo (Dept. of Acupuncture Moxibustion and Acupoint, College of Oriental Medicine, Daegu Haany University) ;
  • Park, In-Sick (Dept. of Anatomy, College of Oriental Medicine, Dongguk University) ;
  • Choi, Nan-Hee (Dept. of Anatomy, College of Oriental Medicine, Dongguk University) ;
  • Kim, Kwang-Joong (Dept. of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Jang, Eun-Young (Dept. of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Ku, Sae-Kwang (Dept. of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University) ;
  • Song, Ick-Soo (Oriental Medical Clinic of Clearhead Hongik) ;
  • Yang, Chae-Ha (Dept. of Physiology, College of Oriental Medicine, Daegu Haany University)
  • 최성훈 (대구한의대학교 한의과대학 해부학교실) ;
  • 이봉효 (대구한의대학교 한의과대학 침구경혈학교실) ;
  • 박인식 (동국대학교 한의과대학 해부학교실) ;
  • 최난희 (동국대학교 한의과대학 해부학교실) ;
  • 김광중 (대구한의대학교 한의과대학 생리학교실) ;
  • 장은영 (대구한의대학교 한의과대학 생리학교실) ;
  • 구세광 (대구한의대학교 한의과대학 해부학교실) ;
  • 송익수 (맑은머리 홍익한의원) ;
  • 양재하 (대구한의대학교 한의과대학 생리학교실)
  • Published : 2009.02.20
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Abstract

Objectives : The mesolimbic dopamine system is believed to play a major role in the reinforcing effect and behavioral hyperactivity of abused drugs including methamphetamine. In the present study, the effect of acupuncture on methamphetamine-induced locomotor activity and c-Fos expression in the striatum and nucleus accumbens of rats were examined. Methods : Male Sprague-Dawley rats received acupuncture at bilateral Yanggu($SI_5$) point for 30seconds immediately before the subcutaneous injection of saline or methamphetamine(0.5mg/kg). The total amount of locomotor activity for 90min were measured just before brain samples were taken for immunohistochemistry. Results : Results showed that acupuncture at the specific point $SI_5$, but not control point(Kunlun, $BL_{60}$) significantly reduced locomotor activity and c-Fos expression in the striatum and nucleus accumbens induced by acute administration of methamphetamine. Conclusions : These results suggest that acupuncture may be effective in suppressing the reinforcing effect of methamphetamine by regulating neuronal activity.

Keywords

References

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