The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Hexane-Soluble Fraction of the Common Fig, Ficus carica, Inhibits Osteoclast Differentiation in Murine Bone Marrow-Derived Macrophages and RAW 264.7 Cells

  • Park, Young-Ran (Department of Dental Pharmacology, School of Dentistry, and Institute of Oral Bioscience, Brain Korea 21 Project, Chonbuk National University) ;
  • Eun, Jae-Soon (College of Pharmacy, Woosuk University) ;
  • Choi, Hwa-Jung (Department of Dental Pharmacology, School of Dentistry, and Institute of Oral Bioscience, Brain Korea 21 Project, Chonbuk National University) ;
  • Nepal, Manoj (Department of Dental Pharmacology, School of Dentistry, and Institute of Oral Bioscience, Brain Korea 21 Project, Chonbuk National University) ;
  • Kim, Dae-Keun (College of Pharmacy, Woosuk University) ;
  • Seo, Seung-Yong (College of Pharmacy, Woosuk University) ;
  • Li, Rihua (College of Pharmacy, Woosuk University) ;
  • Moon, Woo-Sung (Department of Pathology, School of Medicine, Chonbuk National University) ;
  • Cho, Nam-Pyo (Department of Oral Pathology, School of Dentistry, Chonbuk National University) ;
  • Cho, Sung-Dae (Department of Oral Pathology, School of Dentistry, Chonbuk National University) ;
  • Bae, Tae-Sung (Department of Dental Biomaterials, School of Dentistry, Chonbuk National University) ;
  • Kim, Byung-Il (Department of Materials Science and Metallurgical Engineering, Sunchon National University) ;
  • Soh, Yun-Jo (Department of Dental Pharmacology, School of Dentistry, and Institute of Oral Bioscience, Brain Korea 21 Project, Chonbuk National University)
  • Published : 2009.12.31
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Abstract

Osteoclasts, derived from multipotent myeloid progenitor cells, play homeostatic roles in skeletal modeling and remodeling, but may also destroy bone in pathological conditions such as osteoporosis and rheumatoid arthritis. Osteoclast development depends critically on a differentiation factor, the receptor activator of NF-${\kappa}B$ ligand (RANKL). In this study, we found that the hexane soluble fraction of the common fig Ficus carica (HF6-FC) is a potent inhibitor of osteoclastogenesis in RANKL-stimulated RAW264.7 cells and in bone marrow-derived macrophages (BMMs). HF6-FC exerts its inhibitory effects by suppression of p38 and NF-${\kappa}B$ but activation of ERK. In addition, HF6-FC significantly decreased the expression of NFATc1 and c-Fos, the master regulator of osteoclast differentiation. The data indicate that components of HF6-FC may have therapeutic effects on bone-destructive processes such as osteoporosis, rheumatoid arthritis, and periodontal bone resorption.

Keywords

References

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