Korea-Australia Rheology Journal

The Korean Society of Rheology (한국유변학회)
권호 표지

The assessment of the performance of drug-eluting stent using computational fluid dynamics

  • Seo, Tae-Won (School of Mechanical Engineering, Andong National University) ;
  • Barakat, Abdul I. (Deptment of Aeronautical and Mechanical Engineering, University of California)
  • Published : 2009.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Numerical investigations have been conducted on the assessment of the performance of drug-eluting stent. Computational fluid dynamics is applied to investigate the flow disturbances and drug distributions released from the stent in the immediate vicinity of the given idealized stent in the protrusion into the flow domain. Our simulations have revealed the drug concentration in the flow field due to the presence of a drug-eluting stent within an arterial segment. Wall shear stress increases with Reynolds number for a given stent diameter, while it increases with stent diameter for a given Reynolds number. The drug concentration is dependent on both Reynolds number and stent geometry. In pulsatile flow, the minimum drug concentration in the zone of inter-wire spacing occurs at the maximum acceleration of the inlet flow while the maximum drug concentration gains at the maximum deceleration of the inlet flow. These results provide an understanding of the flow physics in the vicinity of drug-eluting stents and suggest strategies for optimal performance of drug-eluting stent to minimize flow disturbance.

Keywords

References

  1. Berry, J. L., A. Santamarina, J. E. Moore, Jr., S. Roychowdhury and W. D. Routh, 2000, Experimental and computational flow evaluation of coronary stent., Ann. Biomed. Eng. 28, 386-398 https://doi.org/10.1114/1.276
  2. Edelman, E. R. and C. Rogers, 1998, Pathobiologic responses to stenting, Am. J. Cardiol 81, 4E-6E https://doi.org/10.1016/S0002-9149(98)00189-1
  3. LaDisa, John F. Jr., L. E. Olson, I. Guler, D. A. Hettrick, S. H. Audi, J. R. Kersten, D. C. Warltier and P. S. Pagel, 2004, Stent design properties and deployment ratio influence indexes of wall shear stress: A three-dimensional computational fluid dynamics investigation within a normal artery, J. Appl Physiol. 97, 424-430 https://doi.org/10.1152/japplphysiol.01329.2003
  4. Reger, E., G. Sianos and P. W. Serruys, 2001, Stent development and local drug delivery. british medical bulletin 59, 227-248 https://doi.org/10.1093/bmb/59.1.227
  5. Garasic, J. M., E. R. Edelman, J. C. Squire, P. Seifert, M. S. Williams and C. Rogers, 2000, Stent and artery geometry determine intimal thickening independent of arterial injury, Circulation 101, 812-818
  6. Bennett, M. R., 2003, In-stent stenosis: pathology and implications for the development of drug eluting stents, Heart 89, 218-224 https://doi.org/10.1136/heart.89.2.218
  7. Morice, M-C., P. W. Serruys, J. E. Sousa, J. Fajadet, E. B. Hayashi, M. Perin, A. Colombo, G. Schuler, P. Barragan, G. Guagliumi, F. MoInar and R. Falotico, 2002, A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization, N. Engl. J. Med. 346, 1773-1780 https://doi.org/10.1056/NEJMoa012843
  8. Moses, J. W., M. B. Leon, J. J. Popma, P. J. Fitzgerald, D. R. Holmes, C. O' Shaughnessy, R. P. Caputo, D. J. Keriakes, D. O. Williams, P. S. Teirstein, J. L. Jaeger and R. E. Kuntz, 2003, Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery, N. Engl. J. Med. 349, 1315-1323 https://doi.org/10.1056/NEJMoa035071
  9. Chong, P. H. and J. W. M. Cheng, 2004a, Early experiences and clinical implications of drug-eluting stents: Part 1, The annals of pharmacotherapy 38, 661-669 https://doi.org/10.1345/aph.1D256
  10. Chong, P. H. and J. W. M. Cheng, 2004b, Early experiences and clinical implications of drug-eluting stents: Part 2, The Annals of Pharmacotherapy 38 845-852 https://doi.org/10.1345/aph.1D261
  11. Suzuki, T., G. Kopia, S. Hayashi and L. R. Bailey, 2001, Stentbased delivery of sirolimus reduces neointimal formation in a porcine coronary model, Circulation 104 1188-1193
  12. Seo, T. W., L. G. Schachter and A. I. Barakat, 2005, Computational study of fluid mechanical disturbance induced by endovascular stents, Annals of Biomedical Eng. 33(4) 444-456 https://doi.org/10.1007/s10439-005-2499-y
  13. Wentzel, J. J., R. Krams, C. H. Schuurbiers, J. A. Oomen, J. Kloet, W. J. van der Giessen, P. W. Serruys and C. J. Slager, 2001, Relationship between neointimal thickness and shear stress after wallstent implantation in human coronary arteries, Circulation 103 1740-1745
  14. Zunino, P., 2004, Multidimensional pharmacokinetic models applied to the design of drug-eluting stents, Cardiovascular Engineering: An lnternational J. 4 181-191 https://doi.org/10.1023/B:CARE.0000031547.39178.cb