Nuclear Medicine and Molecular Imaging

The Korean Society of Nuclear Medicine (대한핵의학회)
권호 표지

A Novel Aromatic Fluorine-18 Labeling Method Using Iodonium Salts Precursor

이오도늄 솔트 전구체를 이용한 새로운 방향족 화합물 플루오린-18 표지 기술

  • Moon, Byung-Seok (Institute of Radiation Medicine, Seoul National University Medical Research Center & Department of Nuclear Medicine, Seoul National University Bundang Hospital) ;
  • Lee, Byung-Chul (Institute of Radiation Medicine, Seoul National University Medical Research Center & Department of Nuclear Medicine, Seoul National University Bundang Hospital) ;
  • Kim, Sang-Eun (Institute of Radiation Medicine, Seoul National University Medical Research Center & Department of Nuclear Medicine, Seoul National University Bundang Hospital)
  • 문병석 (서울대학교 의학연구원 방사선 의학연구소, 분당서울대학교병원 핵의학과) ;
  • 이병철 (서울대학교 의학연구원 방사선 의학연구소, 분당서울대학교병원 핵의학과) ;
  • 김상은 (서울대학교 의학연구원 방사선 의학연구소, 분당서울대학교병원 핵의학과)
  • Published : 2009.02.28
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Abstract

As many new drug substances contained various aromatic rings and fluorine attached to an electron rich aromatic ring or on the meta-position, a strategy towards improvement in aromatic fluorination of these compounds is highly desirable. The introduction of fluorine-18 onto aromatic rings showed in the limited condition containing electron withdrawing group (EWG) on the para- or ortho-position to get reasonable radiochemical yield so far. No-carrier added (NCA) [$^{18}F$]fluoroarene syntheses by iodonium salts recently reported that has the potential to greatly increase the yield in systems or positions that normally not reactive enough to give sufficient yields in simple model reaction. This review describes the methodological approach towards effective aromatic fluorination by diaryliodonium salts and future prospects in an application of novel PET radiotracer.

Keywords

References

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