약학회지 (YAKHAK HOEJI)

  • 제53권1호
  • /
  • Pages.12-18
  • /
  • 2009
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  • 0377-9556(pISSN)
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  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

어성초로부터 분리된 Quercetin의 카드뮴에 대한 독성억제효과

The Inhibitory Effects of Quercetin from Houttuynia cordata against Cadmium-Induced Cytotoxicity

  • 최화정 (생명공학연구원 천연의학연구센터) ;
  • 노용주 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 강정일 (대불대학교 물리치료학과) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Choi, Hwa-Jung (Natural Medicines Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • No, Yong-Ju (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kang, Jeong-Il (Department of Physical Therapy, Daebul University) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 발행 : 2009.02.28
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초록

The aim of this study was to develop antitoxic compound for cadmium-induced cytotoxic Vero cells. These cells were divided into five groups; control group (medium only), cadmium group (cadmium only), and two experimental groups. SRB (sulphorodamine B) assay was performed to evaluate the cytotoxicity of cell organelles. After cadmium was treated on Vero cells, we determined IC50 values to examine the detoxification effects of Houttuynia cordata methanol extract and quercetin under cadmium-induced cytotoxicity. Furthermore, morphological changes were observed by the light microscope. In Vero cells, methanol extract of Houttuynia cordata, and quercetin showed inhibitory effects on cadmium-induced cytotoxicity and these detoxification effects were increased in a concentration-dependent manner. These results suggest that methanol extract and quercetin from Houttuynia cordata retain a potential antitoxic activity.

키워드

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