YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Effect of Litsea japonica on the Apoptosis Induction of HL-60 Leukemia Cells

까마귀쪽나무(Litsea japonica)의 HL-60 백혈병 세포 Apoptosis 유도효과

  • Kim, Elvira (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Cheju National University) ;
  • Boo, Hye-Jin (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Cheju National University) ;
  • Hyun, Jae-Hee (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Cheju National University) ;
  • Kim, Sang-Cheol (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Cheju National University) ;
  • Kang, Jung-Il (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Cheju National University) ;
  • Kim, Min-Kyoung (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Cheju National University) ;
  • Yoo, Eun-Sook (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Cheju National University) ;
  • Kang, Hee-Kyoung (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Cheju National University)
  • 김엘비라 (제주대학교 의학전문대학원 약리학교실, 제주대학교 의과학연구소) ;
  • 부혜진 (제주대학교 의학전문대학원 약리학교실, 제주대학교 의과학연구소) ;
  • 현재희 (제주대학교 의학전문대학원 약리학교실, 제주대학교 의과학연구소) ;
  • 김상철 (제주대학교 의학전문대학원 약리학교실, 제주대학교 의과학연구소) ;
  • 강정일 (제주대학교 의학전문대학원 약리학교실, 제주대학교 의과학연구소) ;
  • 김민경 (제주대학교 의학전문대학원 약리학교실, 제주대학교 의과학연구소) ;
  • 유은숙 (제주대학교 의학전문대학원 약리학교실, 제주대학교 의과학연구소) ;
  • 강희경 (제주대학교 의학전문대학원 약리학교실, 제주대학교 의과학연구소)
  • Published : 2009.02.28
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Abstract

This study investigated the antiproliferative effect of the EtOH extract from Litsea japonica. The extract markedly inhibited the growth of HL-60 cells. When treated with the extract, several apoptosis events like as DNA fragmentation, chromatin condensation and the increase of the population of sub-G1 hypodiploid cells were observed. The extract decreased the Bcl-2 expression, whereas the Bax expression was increased. Caspase-9 and -3 were activated and poly (ADP-ribose) polymerase was cleaved. The results suggest that the antiproliferative effect of L. japonica in HL-60 appears to arise from apoptosis induction via the down-regulation of Bcl-2 and the activation of caspases.

Keywords

References

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