Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Biology of Glioma Cancer Stem Cells

  • Park, Deric M. (University of Pittsburgh Cancer Institute) ;
  • Rich, Jeremy N. (Department of Stem Cell Biology and Regenerative Medicine Cleveland Clinic)
  • Received : 2009.07.06
  • Accepted : 2009.07.09
  • Published : 2009.07.31
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Abstract

Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and non-neoplastic cells that include both native and recruited cells. There is extensive diversity among the tumor cells, with differing capacity for In vitro and in vivo growth, a property intimately linked to the cell's differentiation status. Those cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells are designated by some as cancer stem cells, because of the stem-like properties. These cells may be a critical therapeutic target. However the exact identity and cell(s) of origin of the socalled glioma cancer stem cell remain elusive. Here we review the current understanding of glioma cancer stem cell biology.

Keywords

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