Analytical Science and Technology (분석과학)

The Korean Society of Analytical Sciences (한국분석과학회)
권호 표지
DOI QR코드

DOI QR Code

Distribution of hazardous heavy metals in commercial herbal medicines classified by plant parts used in seoul

서울지역 유통한약재의 약용부위에 따른 유해중금속 분포

  • Kim, Donggyu (Seoul Metropolitan Government Research Institute of Public Health and Environment) ;
  • Kim, Bogsoon (Seoul Metropolitan Government Research Institute of Public Health and Environment) ;
  • Han, Eunjung (Seoul Metropolitan Government Research Institute of Public Health and Environment) ;
  • Han, Changho (Seoul Metropolitan Government Research Institute of Public Health and Environment) ;
  • Kim, Oukhee (Seoul Metropolitan Government Research Institute of Public Health and Environment) ;
  • Choi, Byunghyun (Seoul Metropolitan Government Research Institute of Public Health and Environment) ;
  • Hwang, Insook (Seoul Metropolitan Government Research Institute of Public Health and Environment) ;
  • Chae, Youngzoo (Seoul Metropolitan Government Research Institute of Public Health and Environment) ;
  • Kim, Minyoung (Seoul Metropolitan Government Research Institute of Public Health and Environment) ;
  • Park, Seungkook (Institute of Life Science and Resources, Kyung Hee University)
  • Received : 2009.09.29
  • Accepted : 2009.10.27
  • Published : 2009.12.25
Download PDF
⟨ Previous Next ⟩

Abstract

In this study, the safety of commercial herbal medicines was evaluated by determining concentration of hazardous heavy metals. 3,152 samples (244 types) purchased by individual packing unit from market in Seoul, were analyzed using ICP-MS and mercury analyzer. As a result, the content (mg $kg^{-1}$) of Pb was higher in the above-ground part (0.92) than underground part (0.43). But in case of As and Cd contents, there is slightly higher in the underground-parts (0.26, 0.13) than the above-ground parts (0.18, 0.08). There were many herbal medicines exceeding regulatory limits of Cd comparing with other metals. The levels of Hg seemed to be different between above-ground part(0.009) and underground part (0.008) but there was no sample exceeding tolerance limits. In the comparison of imported samples with domestic herbal medicines, it was shown that Pb, As, and Hg were measured highly in the imported ones, Cd was not significantly different (t-test, p<0.05). The significant correlation was observed between Pb and As (r=0.386, p<0.01) but there was no difference in other parts. The heavy metal contamination of herbal medicines measured in total amount of respective heavy metals (mg $kg^{-1}$) was high in Flos (6.241) and Caulis (2.238), and decreased in the order of Cortex (1.634), Herba (1.154), Perithecium (0.861), Rhizoma (0.828), Radix (0.825), Fructus (0.475), and was low in Semen (0.422) (ANOVA-test, p<0.05).

본 연구는 유통한약재에 대한 중금속의 안전성을 약용부위에 따른 유해중금속의 함량으로 평가 하였다. 시료는 서울지역에서 포장단위로 구매된 244품목 3152건을 대상으로 ICP-MS와 수은분석기로 분석하였다. 납의 함량(mg $kg^{-1}$)은 한약재의 지상부(0.92)가 지하부(0.43)보다 높았다. 그러나 비소는 지하부(0.26)와 지상부(0.18)으로 차이가 있었고, 카드뮴도 지하부(0.13)가 지상부 (0.08)보다 높았다. 유통한약재에서 카드뮴의 기준을 초과한 건수가 다른 유해중금속에 비교하여 많았다. 수은은 지상부(0.009)와 지하부(0.008)에서 유의적인 차이가 있었으나, 수은의 기준을 초과한 시료는 없었다(t-test, p<0.05). 원산지간의 비교에서, 납, 비소, 수은은 국산보다 수입산 한약재가 중금속의 함량이 높았으나, 카드뮴에서는 차이가 없었다(t-test, p<0.05). 납, 비소, 카드뮴, 수은 사이의 상관관계는 납은 비소와 상관관계(r=0.386)를 보였으나, 다른 부위에서는 관계가 적었다 (p<0.01). 약용부위에 따른 개별중금속의 합(mg $kg^{-1}$)은 씨(0.422), 과실부위(0.475)가 적었고, 뿌리(0.825), 뿌리줄기부위(0.828), 버섯부위(0.861)가 다음이고, 잎(1.154), 표피(1.634), 줄기(2.238), 꽃부위(6.241)의 순으로 중금속 오염이 심했다 (ANOVA-test, p<0.05).

Keywords

References

  1. 박창호, 강신인, '한약재포제기술', 15, 청문각, 한국, 2006
  2. 식품의약품안전청, 고시 제2009-35호, 2009
  3. 한의약육성법, 법률 제6965호(2003.8.6)
  4. 식품의약품안전청, '한약재표준제조공정지침', 3, 2008
  5. 한국보건산업진흥원, '한약품질및유통관리제도 조사 연구', 2, 한국, 2000
  6. G. B. Jung, B.Y. Kim, K. S. Kim, J.S. Lee and I. S. Ryu, Korean J. Soil Sci. Fert., 29, 158(1996)
  7. G. G. S. Holmgren, M. W. Meyer, R. L. Chaney and R. B. Daniels, American J. Environ. Qual., 22, 335(1993) https://doi.org/10.2134/jeq1993.00472425002200020015x
  8. 김형국, '약전해설서', 346, 파마코리아나, 한국, 2008
  9. S. D. Lee, and K. S. Park, Korean J. Oriental Preventive Medical Society, 5, 31(2001)
  10. J. S. Kim, S. W. Hwang, J. M. Kim and J. Y. MA, Korean J. Yakhak Hoeji, 45, 448(2001)
  11. J. H. Kim, J. Y. Yang and Y. S. Moon, Korean J. of the Environmental Sciences, 16, 1287(2007) https://doi.org/10.5322/JES.2007.16.11.1287
  12. Y. Y. Cha, S. K., Hea, B. C. Cha and S. H. Sea, Korean J. Oriental Physiology & Pathology, 21, 226(2007)
  13. D. H. Jung and M. K. Park, Korean J. of the Environmental Sciences, 17, 129(2008) https://doi.org/10.5322/JES.2008.17.1.129
  14. S. H. Lee, H. Y. Choi and C. H. Park, Korean J. of Biotechnol Bioeng., 18, 90(2003)
  15. M. K. Park, Korean J. of the Env. Sci., 16, 241(2007) https://doi.org/10.5322/JES.2007.16.2.241
  16. S. D. Lee, H. M. Park, J. C. Lee and Y. B, Kook, Korean J. of Oriental Med., 24, 59(2003)
  17. 서부일, 이제현, 최호영, 권동렬, 부영민, '한약본초학', 29, 영림사, 한국, 2006
  18. 한국의약품수출입협회, '한약재감별주해', 15-38, 대영, 한국, 2003
  19. Y. Shin, J. E. Kwak, C. H. Han, Y. S. Hwang, A. S. Park, D. G. Kim, E. J. Han, S. J. Jung, B. S. Kim, B. H. Choi, Report of Seoul Institute of Health and Enviroment, Korea, 43, 226(2007)
  20. J. E. Kwak, Y. Shin, C. H. Han, Y. S. Hwang, A. S. Park, D. G. Kim, E. J. Han, S. J. Jung, B. S. Kim, B. H. Choi and M. Y. Kim, Report of Seoul Institute of Health and Enviroment, Korea, 43, 129(2007)
  21. I. S. Yu and Y. J. Hong, Report of Seoul Institute of Health and Enviroment, Korea, 42, 62(2006)
  22. Y. J. Hong, J. E. Kwak, W. H. Park, Y. S. Hwang, E. J. Kim, A. S. Park, Y. Shin, E. J. Han, J. M. Lee, B. S. Kim and B. Y. Choi, Report of Seoul Institute of Health and Enviroment, Korea, 42, 286(2006)
  23. KOLAS (Korea Laboratory Accreditation Scheme), KT208호
  24. 김복순, 단국대학교 박사학위논문, 58(2007)
  25. 영인과학, 'ICP-MS 입문서', 28-39, 한국, 2005
  26. Raymond Niesink, Mannfred A. Hollinger, John De Vries, 'Toxicology-Principles and Applicationsv, 17-38, CRC Press, Inc., Florida, USA, 1996