BMB Reports

Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
권호 표지
DOI QR코드

DOI QR Code

Oenanthe javanica extract accelerates ethanol metabolism in ethanol-treated animals

  • Kim, Jong-Yeon (Department of Physiology, College of Medicine, Yeungnam University) ;
  • Kim, Ki-Hoon (Department of Physiology, College of Medicine, Yeungnam University) ;
  • Lee, Youn-Ju (Department of Physiology, College of Medicine, Yeungnam University) ;
  • Lee, Seung-Ho (College of Pharmacy, Yeungnam University) ;
  • Park, Jong-Cheol (Department of Oriental Medicine Resources, Sunchon National University) ;
  • Nam, Doo-Hyun (College of Pharmacy, Yeungnam University)
  • Published : 2009.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

The effect of water dropwort (Oenanthe javanica DC) extract in eliminating ethanol was evaluated in New Zealand white rabbit and ICR mice. When a hot-water extract of water dropwort extract and ethanol was injected into New Zealand white rabbit, the plasma ethanol level was rapidly reduced, similar to metadoxine treatment. Specifically, the n-butanol fraction of hot-water extract was the strongest in eliminating plasma alcohol in ICR mice. When ethanol was orally ingested, administration of the hot-water extract eliminated up to 44% of the plasma ethanol in mice while the n-butanol fraction eliminated around 70%. Alcohol removal behaved in a dose-dependent manner in response to 50-200 mg/kg of n-butanol fraction. These data show O. javanica extract is effective in overcoming alcohol intoxication by the accelerating ethanol metabolism.

Keywords

References

  1. Ji, G., Yao, X., Zang, Z. and Huang, Z. (1990) Antiarrhythmic effect of Oenanthe javanica (Bl.) DC. injection. Zhongguo Zhong Yao Za Zhi 15, 429-431
  2. Yang, X. B., Huang, Z. M., Cao, W. B., Zheng, M. Chen, H. Y. and Zhang, J. G. (2000) Antidiabetic effect of Oenanthe javanica flavone. Acta Pharmacol. Sin. 21, 239-242
  3. Han, Y. Q., Huang, Z. M., Yang, X. B., Liu, H. Z. and Wu, G. X. (2008) In vivo and in vitro anti-hepatitis B virus activity of total phenolics from Oenanthe javanica. J. Ethnopharmacol. 118, 148-153 https://doi.org/10.1016/j.jep.2008.03.024
  4. Wang, W. N., Yang, X. B., Liu, H. Z., Huang, Z. M. and Wu, G. X. (2005) Effect of Oenanthe javanica flavone on human and duck hepatitis B virus infection. Acta Pharmacol. Sin. 26, 587-592 https://doi.org/10.1111/j.1745-7254.2005.00055.x
  5. Cho, H. W., Lee, S. H., Nam, D. H., Kim, J. Y., Lim, S. K., Lee, J. S. and Park, J. H. (2008) Antioxidative activity and phytochemical study on the aerial parts of Oenanthe javanica. Korean J. Pharmacogn. 39, 142-245
  6. Park, J. C., Young, H. S., Yu, Y. B. and Lee, J. H. (1995) Isorhamnetin sulphate from the leaves and stems of Oenanthe javanica in Korea. Planta Med. 61, 377-378 https://doi.org/10.1055/s-2006-958110
  7. Park, J. C., Kim, J. Y., Lee, Y. J., Lee, J. S., Kim, B. G., Lee, S. H. and Nam, D. H. (2008) Protective effect of Oenanthe javanica extract on acetaminophen-induced hepatotoxicity in rats. Yakhak Hoeji 52, 316-321
  8. Park, J. C., Yu, Y. B., Lee, J. H., Hattori, M., Lee, C. K. and Choi, J. W. (1996) Protective effect of Oenanthe javanica on the hepatic lipid peroxidation in bromobenzene-treated rats and its bioactive component. Planta Med. 62, 488-490 https://doi.org/10.1055/s-2006-957954
  9. Park, J. C. and Choi, J. W. (1997) Effects of methanol extract of Oenanthe javanica on the hepatic alcohol-metabolizing enzyme system and its bioactive component. Phytother. Res. 11, 260-262 https://doi.org/10.1002/(SICI)1099-1573(199705)11:3<260::AID-PTR80>3.0.CO;2-N
  10. Wiese, J. G., Shlipak, M. G. and Browner, W. S. (2000) The alcohol hangover. Ann Intern. Med. 132, 897-902 https://doi.org/10.7326/0003-4819-132-11-200006060-00008
  11. Bogin, R. M., Nostrant, T. T. and Young, M. J. (1987) Propanolol for the treatment of the alcoholic hangover. Amer. J. Alcohol Abuse 13, 175-180 https://doi.org/10.3109/00952998709001507
  12. Stickel, F., Hoehn, B., Schuppan, D. and Seitz, H. K. (2003) Nutritional therapy in alcohol liver damage. Aliment. Pharmacol. Ther. 18, 357-373 https://doi.org/10.1046/j.1365-2036.2003.01660.x
  13. Calabrese, V., Calderone, A., Ragusa, N. and Rizza, V. (1996) Effects of metadoxine on cellular status of glutathione and of enzymatic defence system following acute ethanol intoxication in rats. Drugs Exp. Clin. Res. 22, 17- 24

Cited by

  1. Root extract of water dropwort, Oenanthe javanica (Blume) DC, induces protein and gene expression of phase I carcinogen-metabolizing enzymes in HepG2 cells vol.5, pp.1, 2016, https://doi.org/10.1186/s40064-016-2078-8
  2. Hepatoprotective effects of fermented field water-dropwort (Oenanthe javanica) extract and its major constituents vol.67, 2014, https://doi.org/10.1016/j.fct.2014.02.010
  3. The protective effect of total phenolics from Oenanthe Javanica on acute liver failure induced by D-galactosamine vol.186, 2016, https://doi.org/10.1016/j.jep.2016.03.024
  4. De novo transcriptome assembly, gene annotation, marker development, and miRNA potential target genes validation under abiotic stresses in Oenanthe javanica vol.290, pp.2, 2015, https://doi.org/10.1007/s00438-014-0953-y
  5. GABA-enriched water dropwort produced by co-fermentation with Leuconostoc mesenteroides SM and Lactobacillus plantarum K154 vol.73, 2016, https://doi.org/10.1016/j.lwt.2016.06.002
  6. Persicarin isolated from Oenanthe javanica protects against diabetes-induced oxidative stress and inflammation in the liver of streptozotocin-induced type 1 diabetic mice vol.13, pp.4, 2017, https://doi.org/10.3892/etm.2017.4113
  7. Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder vol.21, pp.1, 2016, https://doi.org/10.3390/molecules21010064
  8. Selection of Suitable Reference Genes for qPCR Normalization under Abiotic Stresses in Oenanthe javanica (BI.) DC vol.9, pp.3, 2014, https://doi.org/10.1371/journal.pone.0092262