Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Effect of PCB118 on expression of COX-2 and cPLA2 in rat testes

  • Han, Dae-Yong (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University) ;
  • Park, Kwang-Il (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University) ;
  • Park, Hyeon-Soo (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University) ;
  • Kang, Sang-Rim (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University) ;
  • Cho, Jae-Hyeon (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hu-Jang (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Eun-Hee (Department of Physical Therapy, International University of Korea) ;
  • Kim, Gon-Sup (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University)
  • Accepted : 2009.12.01
  • Published : 2009.12.31
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Abstract

Polychlorinated biphenyls (PCBs) are synthetic organic compounds with two benzene rings and well known environmental pollutants. This study examined the effect of persistent exposure to 2,$3^{\prime}$,4,$4^{\prime}$,5-pentachlorobiphenyl (PCB118) on the proinflammatory and proapoptotic factors in male rats. Male Sprague Dawley rats were administered weekly intraperitoneal injections of either PCB118 (20 mg/kg) dissolved in corn oil or corn oil alone. One week after 2 and 5 administrations, the rats were sacrificed by a pentobarbital injection. The effect of PCB118 on the expression of cyclooxygenase 2 (COX-2), cytosolic phospholipase A2 (cPLA2), peroxisome proliferator-activated receptor gamma, Bcl and Bcl-2-associated X protein (BAX) was investigated. The level of COX-2 and cPLA2 expression was higher in the PCB118-treated rats than the control. These results suggest that PCB118 has a proinflammatory effect in rats.

Keywords

References

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