Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
권호 표지

Adhesion Prevention with Guardix® (Sodium Hyaluronate) After Flexor Tendon Repair in Rabbits

토끼 모델에서 굴근 인대 봉합 후 가딕스®의 유착 방지 효과

  • Kim, Hark Young (Department of Plastic and Reconstructive Surgery, Research Institue of Plastic and Reocnsturctive Sugery (RIPRS), College of Medicine, Seoul National University) ;
  • Chang, Hak (Department of Plastic and Reconstructive Surgery, Research Institue of Plastic and Reocnsturctive Sugery (RIPRS), College of Medicine, Seoul National University) ;
  • Minn, Kyung Won (Department of Plastic and Reconstructive Surgery, Research Institue of Plastic and Reocnsturctive Sugery (RIPRS), College of Medicine, Seoul National University)
  • 김학영 (서울대학교 의과대학 성형외과학 교실 성형재건연구소) ;
  • 장학 (서울대학교 의과대학 성형외과학 교실 성형재건연구소) ;
  • 민경원 (서울대학교 의과대학 성형외과학 교실 성형재건연구소)
  • Published : 2009.09.15
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Abstract

Purpose: Adhesion is the most common and troublesome complication after repair of flexor tendon injury. Recently, use of sodium hyaluronate derivatives for adhesion prevention is increasing. A commercial product, Guardix$^{(R)}$, sodium hyaluronate(NaHe) combined with carboxymethylcellulose(CMC) has been newly developed as a preventive material for adhesion. We have investigated its effect in rabbits. Methods: Twenty seven male New Zealand white rabbits were operated under ketamine anesthesia. After tendon repair in zone II of the hind paw, Guardix$^{(R)}$(experimental group) or normal saline(control group) was administered. Biomechanical tests were performed to estimate adhesion formation at 2, 4, 8, and 12 weeks after the operation. Maximum tensile load to flex the distal interphalangeal joint 50 degree from its resting state(MTL50) was measured, depicting the amount of adhesion formed. Subsequently, breaking strength was assessed. Results: There were no postoperative complications such as infection, wound dehiscence, or hematoma. MTL50 was significantly lower in the experimental group than in the control group at 4, 8, 12 weeks (p<0.05). Mean value of MTL50 was 6.64N in the experimental group and 28.53N in the control group at 12 weeks after surgery. There were no significant differences in breaking strength. Conclusion: Our results indicate that Guardix$^{(R)}$ is helpful in reducing adhesion formation and does not interfere with normal healing processes of the tendon.

Keywords

Acknowledgement

Supported by : 한국과학재단

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