Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Association of GHRH, H-FABP and MYOG Polymorphisms with Economic Traits in Pigs

  • Cho, Eun Seok (Department of Animal Resources Technology, Jinju National University) ;
  • Park, Da Hye (Department of Animal Resources Technology, Jinju National University) ;
  • Kim, Byeong-Woo (Division of Applied Life Science, Institute of Agriculture and Life Sciences, Gyeongsang National University) ;
  • Jung, Won Youg (Department of Animal Resources Technology, Jinju National University) ;
  • Kwon, Eun Jung (Department of Animal Resources Technology, Jinju National University) ;
  • Kim, Chul Wook (Department of Animal Resources Technology, Jinju National University)
  • Received : 2007.12.14
  • Accepted : 2008.04.04
  • Published : 2009.03.01
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Abstract

The study of candidate genes is an important tool to identify genes associated with economic traits. Three genes were selected to study the association between polymorphism and economic traits and breed of pigs. Growth hormone releasing hormone (GHRH) takes part in growth metabolism and is one of the candidate genes known to be highly associated with economic traits in pigs. Heart fatty acid-binding protein (H-FABP) is related to back fat thickness and intramuscular fat (IMF) content, and myogenin (MYOG) is associated with the amount of growth rate and lean yield in pigs. By PCR-RFLP analysis, the association between the genotypes of the three genes and the average daily gain, back fat thickness, feed conversion, body length and meat percent in 352 pigs (112 Duroc pigs, 132 Landrace pigs and 108 Yorkshire pigs) were analyzed. GHRH polymorphisms showed differences depending on breed (p<0.01) and were associated with meat percent. H-FABP polymorphisms also showed significant differences among breeds and sex (p<0.01), and were highly associated with average daily gain, feed conversion and back fat thickness (p<0.01) and even showed an association with meat percent (p<0.05). However, the MYOG gene showed no significant effect in this study. These results reconfirmed that GHRH and H-FABP are potential major genes or markers for economic traits.

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References

  1. Alfonso, L. and A. Arana. 2004. Characterization of some fatness candidate genes in Basque black pied and Large White pigs. Archivos de zootecnia 53:411-414
  2. Alfonso, L., J. Mourot, K. Insausti, J. A. Mendizabal and A. Arana. 2005. Comparative description of growth, fat deposition, carcass and meat quality characteristic of Basque and Large White pigs. Anim. Res. 54:33-42 https://doi.org/10.1051/animres:2005001
  3. Anton, I., L. Fesus and A. Zsolnai. 2002. Simultaneous identification of two MspI polymorphisms of the porcine myogenin gene in Hungarian breeds. J. Anim. Breed. Genet. 119:280-283 https://doi.org/10.1046/j.1439-0388.2002.00343.x
  4. Baskin, L. C. and D. Pomp. 1997. Rapid communication: Restriction fragment length polymorphism in amplification products of the porcine growth hormone- releasing hormone gene. J. Anim. Sci. 75(8):2285
  5. Cieslak, D., W. Kapelanksi, T. Blicharski and M. Pierzchala. 2000. Restriction fragment length polymorphism in myogenin and MYF-3 genes and their influence on lean meat content in pigs. J. Anim. Breed. Genet. 117:43-55 https://doi.org/10.1046/j.1439-0388.2000.00209.x
  6. Cogan, J. D. and J. A. Phillips 3rd. 1998. Growth disorders caused by genetic defects in the growth hormone pathway. Adv Pediatr. 45:337-361 https://doi.org/10.1016/S1043-2760(99)00226-X
  7. Ernst, C. W. and M. E. Davis. 1995. Characterization of regulatory genes involved in the development of porcine muscle. From the Research Investment Report, The Ohio State University, Ohio
  8. Gerbens, F., A. J. M. van Erp, F. L. Harders, F. J. Verburg, T. H. E. Meuwissen, J. H. Veerkamp and M. F. W. te Pas. 1999. Effect of genetic variants of the heart fatty acid-binding protein gene on intramuscular fat and performance traits in pigs. J. Anim. Sci. 77:846-852 https://doi.org/10.1186/1471-2156-8-55
  9. Handel, S. E. and N. C. Stickland. 1988. Catch-up growth in pigs: relationship with muscle cellularity. Anim. Prod. 46:291-295 https://doi.org/10.1016/0301-6226(94)00050-H
  10. Kim Young Seol. 1990. Clinical applications of growth hormone releasing hormone. J. Kor. Soc. Endocrinol. 5:1
  11. Mauricio, M. Franco, Robson C. Antunes, Heyder D. Silva and Luiz R. Goulart. 2005. Association of PIT1, GH, GHRH polymorphisms with performance and carcass traits in Landrace pigs. J. Appl. Genet. 46(2):195-200
  12. Moody, D. E., D. Pomp and W. Barendse. 1995. Rapid communication: restriction fragment length polymorphism in amplification products of the bovine growth hormonereleasing hormone gene. J. Anim. Sci. 73:3789
  13. Nechtelberger, D., V. Pires, J. Solkner, I. Stur, G. Brem, M. Mueller and S. Mueller. 2001. Intramuscular fat content and genetic variants at fatty acid-binding protein loci in Austrian pigs. J. Anim. Sci. 79:2798-2804
  14. Olson, E. N. 1990. MyoD family: A paradigm for development? Genes Dev. 4:1454-1461 https://doi.org/10.1101/gad.4.9.1454
  15. Soumillion, A., J. H. F. Erkens, J. A. Lenstra, G. Rettenberger and M. F. W. te pas. 1997. Genetic variation in the porcine myogenin gene locus. Mamm. Genome 8:564-568 https://doi.org/10.1007/s003359900504
  16. Te pas, M. F. W., A. Soumillion, F. L. Harders, F. J. Verburg, T. J. van den Bosch, P. Galesloot and T. H. E. Meuwissin. 1999. Influences of myogenin genotypes on birth weight, growth rate, carcass weight, backfat thickness, and lean weight of pigs. J. Anim. Sci. 77:2353-2356
  17. Veerkamp, J. H. and R. G. H. J. Maatman. 1995. Cytoplasmic fatty acid binding protein: Their structure and genes. Prog. Lipid Res. 34:17-52 https://doi.org/10.1016/0163-7827(94)00005-7
  18. Verner, J., P. Humpolicek and A. Knoll. 2007. Impact of MYOD family genes on pork traits in Large White and Lacdrace pigs. J. Anim. Breed. Genet. 124:81-85 https://doi.org/10.1111/j.1439-0388.2007.00639.x
  19. Weintraub, H., R. Davis, S. Tapscott, M. Thayer, M. Krause, R. Benezra, T. K. Blackwell, D. Turner, R. Rupp, S. Hollenberg, Y. Zhuang and A. Lassar. 1991. The MyoD gene family: Nodal point during specification of the muscle cell lineage. Sci. (Wash DC) 251:761-766 https://doi.org/10.1126/science.1846704
  20. Xia, G., M. Qingyong, Weiwu Jin and Ning Li. 2007. Improved expression of muscle-derived growth hormone releasing hormone from α-skeletal-muscle actin enhancer/cytomegalovirus. Asian-Aust. J. Anim. Sci. 20(5):784-788

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