Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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Treatment of Diabetic Ulcer Using Autologous Fibroblast-Hyaluronic Acid Complex

자가 섬유아세포-히알루론산 복합체를 이용한 당뇨발의 치료

  • Eum, Soo Jin (Department of Plastic Surgery Korea University College of Medicine) ;
  • Han, Seung Kyu (Department of Plastic Surgery Korea University College of Medicine) ;
  • Gu, Ja Hea (Department of Plastic Surgery Korea University College of Medicine) ;
  • Jeong, Seong Ho (Department of Plastic Surgery Korea University College of Medicine) ;
  • Kim, Woo Kyung (Department of Plastic Surgery Korea University College of Medicine)
  • 엄수진 (고려대학교 의과대학 성형외과학교실) ;
  • 한승규 (고려대학교 의과대학 성형외과학교실) ;
  • 구자혜 (고려대학교 의과대학 성형외과학교실) ;
  • 정성호 (고려대학교 의과대학 성형외과학교실) ;
  • 김우경 (고려대학교 의과대학 성형외과학교실)
  • Published : 2009.09.15
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Abstract

Purpose: To evaluate clinical efficacy and safety of hyaluronic acid based autologous dermal fibroblasts (Hyalograft 3D) in the treatment of diabetic foot ulcers. Methods: A total of 28 patients with diabetic ulcers were randomized to either the control group with nonadherent foam dressings(n=14) or the treatment group with autologous tissue - engineered grafts(n=14). Weekly assessment contained vital sign checks, ulcer size measurements, and wound photos. At 12th week, percentages of complete wound healing and mean healing times were compared. Safety was also monitored by adverse events. Results: Complete wound healing was achieved in 84.6% of the treatment group and 23.1% of the control group (p<0.005). The mean times of closures for the treatment versus control groups were 6.1 weeks and 10.9 weeks, respectively. No adverse events related to the study treatment occurred. Conclusion: The use of hyaluronic acid based autologous fibroblast grafts was found to be a safe and effective treatment for diabetic foot ulcers.

Keywords

References

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