백서에서 스테로이드 투여가 창상 파열장력에 미치는 영향

The Effect of Administration of Steroid on the Wound Breaking Tensile Strength in Rats

  • 권남호 (중앙대학교 의과대학 성형외과학 교실) ;
  • 김한구 (중앙대학교 의과대학 성형외과학 교실) ;
  • 김우섭 (중앙대학교 의과대학 성형외과학 교실) ;
  • 배태희 (중앙대학교 의과대학 성형외과학 교실)
  • Kwon, Nam Ho (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Kim, Han Koo (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Kim, Woo Seob (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Bae, Tae Hui (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University)
  • 발행 : 2009.09.15

초록

Purpose: The successful wound healing means the scarless wound with adequate strength. It has been shown in vivo and in vitro that steroid retard the collagen synthesis. We studied the effect of steroid on the wound breaking strength in rats. Methods: 40 Sprague - Dawley rats were evenly assigned to two groups. One group was served as control, the other group was experimental. We made dorsal midline incision and closed the wound. In the experimental group, we medicated methylprednisolone (0.15 mg/g/day) for 1 week. Then, we compared the differences of the breaking strength and microscopic histology between control and experimental group at 2, 4, 6 and 8 week. Results: Up to 4 week, the breaking strength of the experimental group was markedly decreased than that of control group, while at 6 week the strength of experimental group attained to that of control group nearly. In histologic findings, control group demonstrated dense organization of collagen to experimental group at 4th week. Conclusion: In this experiment, steroid significantly inhibited the strength gain in wound at early period of the wound healing process. When using steroid after the surgery or the wound formation, it is desirable to administrate carefully and need thorough wound management to prevent delayed wound healing.

키워드

과제정보

연구 과제 주관 기관 : 중앙대학교

참고문헌

  1. Kang JS: Plastic Surgery. 3rd ed. pp108. Kunja, Seo
  2. Garber MW, Aziz AM, Shang X, Penmetsa R, Sabek OM, Yen MR, Gaber LW, Moore LW, Gaber AO: Changes in abdominal wounds following treatment with silorimus and steroids in a rat model. Transplant Proc 38: 3331, 2006 https://doi.org/10.1016/j.transproceed.2006.10.047
  3. Derya U, Ali N, Ayse P, Ulku C., Celal B, Nurten R: The Effect of Corticosteroids on The Healing of Tracheal Anastomoses in a Rat Model. J Phar Res 45: 299, 2002
  4. Del Rio JV, Beck DE, Opelka FG: Chronic perioperative steroids and colonic anastomotic healing in rats. J Surg Re 66: 138, 1995 https://doi.org/10.1006/jsre.1996.0385
  5. George B, Jeffrey EJ: Wound healing: An overview. J Plast Reconstr Surg 117: 1, 1976
  6. Mathes, Stephen J: Plastic Surgery. 2nd ed. In Wound Healing : Repair Biology and Wound and Scar treatment, H. Peter Lorenz, Michael T. Longaker. p 224-225. Saunders Elsevier, Philadelphia, USA, 2006
  7. Cornacoff JB, Howk K, Pikounis B, Mendenhall V, Martin P: Development of a method for the evaluation of wound tensile strength in cynomolgus macaques. J Pharmacol Toxicol Methods 57: 74, 2008 https://doi.org/10.1016/j.vascn.2007.08.002
  8. Hatz RA, Kelley SF, Ehrlich HP: The tetrachlorodecaoxygen complex reverses the effect of cortisone on wound healing. Plast Reconstr Surg 84: 953, 1989 https://doi.org/10.1097/00006534-198912000-00015
  9. Jurjus A, Atiyeh BS, Abdallah IM, Jurjus RA, Hayek SN, Jaoude MA, Gerges A, Tohme RA: Pharmacological modulation of wound healing in experimental burns. Burns 33: 892, 2007 https://doi.org/10.1016/j.burns.2006.10.406
  10. Saulis AS, Moqford JH, Mustoe TA: Effect of mederma on hypertrophic scarring in the rabbit ear model. J Plast Reconstr Surg 110: 177, 2002 https://doi.org/10.1097/00006534-200207000-00029
  11. Beckert S, Haack S, Hierlemann H, Farrahi F, Mayer P, Konigsrainer A, Coerper S: Stimulation of steroid-suppressed cutaneous healing by repeated topical application of IGF-I: different mechanisms of action based upon the mode of IGF-I delivery. J Surg Res 139: 217, 2007 https://doi.org/10.1016/j.jss.2006.08.006