Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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The Effect of Administration of Steroid on the Wound Breaking Tensile Strength in Rats

백서에서 스테로이드 투여가 창상 파열장력에 미치는 영향

  • Kwon, Nam Ho (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Kim, Han Koo (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Kim, Woo Seob (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Bae, Tae Hui (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University)
  • 권남호 (중앙대학교 의과대학 성형외과학 교실) ;
  • 김한구 (중앙대학교 의과대학 성형외과학 교실) ;
  • 김우섭 (중앙대학교 의과대학 성형외과학 교실) ;
  • 배태희 (중앙대학교 의과대학 성형외과학 교실)
  • Published : 2009.09.15
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Abstract

Purpose: The successful wound healing means the scarless wound with adequate strength. It has been shown in vivo and in vitro that steroid retard the collagen synthesis. We studied the effect of steroid on the wound breaking strength in rats. Methods: 40 Sprague - Dawley rats were evenly assigned to two groups. One group was served as control, the other group was experimental. We made dorsal midline incision and closed the wound. In the experimental group, we medicated methylprednisolone (0.15 mg/g/day) for 1 week. Then, we compared the differences of the breaking strength and microscopic histology between control and experimental group at 2, 4, 6 and 8 week. Results: Up to 4 week, the breaking strength of the experimental group was markedly decreased than that of control group, while at 6 week the strength of experimental group attained to that of control group nearly. In histologic findings, control group demonstrated dense organization of collagen to experimental group at 4th week. Conclusion: In this experiment, steroid significantly inhibited the strength gain in wound at early period of the wound healing process. When using steroid after the surgery or the wound formation, it is desirable to administrate carefully and need thorough wound management to prevent delayed wound healing.

Keywords

Acknowledgement

Supported by : 중앙대학교

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