악성 흑색종에 대한 14년간의 임상적 고찰

Clinical Study of Malignant Melanoma for recent 14 years

  • 박동하 (아주대학교 의과대학 성형외과학교실) ;
  • 서승조 (아주대학교 의과대학 성형외과학교실) ;
  • 박명철 (아주대학교 의과대학 성형외과학교실) ;
  • 배남석 (아주대학교 의과대학 성형외과학교실) ;
  • 이일재 (아주대학교 의과대학 성형외과학교실)
  • Park, Dong Ha (Department of Plastic and Reconstructive Surgery, School of Medicine, Ajou University) ;
  • Seo, Seung Jo (Department of Plastic and Reconstructive Surgery, School of Medicine, Ajou University) ;
  • Park, Myong Chul (Department of Plastic and Reconstructive Surgery, School of Medicine, Ajou University) ;
  • Pae, Nam Suk (Department of Plastic and Reconstructive Surgery, School of Medicine, Ajou University) ;
  • Lee, Il Jae (Department of Plastic and Reconstructive Surgery, School of Medicine, Ajou University)
  • 발행 : 2009.05.15

초록

Purpose: Recently, the incidence of malignant melanoma has been steadily increasing. Malignant melanoma is already known to have poorer prognosis than other primary skin cancers. Despite the poor prognosis, it is relatively less known to the public so that a number of patients visit hospital carrying advanced stage tumor. Yet, extensive study about malignant melanoma is currently insufficient, and specific guidelines and statistical figures in Korea are almost inexistent. Therefore, authors reviewed patients with malignant melanoma who have visited our hospital for last 14 years. Methods: Between January 1994 and January 2008, 62 patients were diagnosed with malignant melanoma at our hospital. A retrospective study was performed with data from patients' charts and biopsy results. Annual incidence, mean age of onset, gender, tumor location, tumor thickness, pathologic ulceration, clinicopathologic subtype, and clinical AJCC stage were evaluated. Analysis of factors associated with survival were performed using the Cox proportional hazard model. Kaplan - Meier method was used to generate survival curves. Results: Clinicopathologic features of 62 patients (32 male, 30 female) with average age of 57 years were evaluated. Most lesions were found in lower limb, and the most common subtype was acral lentiginous melanoma. We could also find that age, tumor thickness, and clinical stage were the only significant prognostic factors. Conclusion: Clinicopathologic features of malignant melanoma were analyzed in this study, but the result is not ready to be generalized because the number of cases is too small. Further study must be performed to report clinical guidelines for prognosis and treatment for malignant melanoma patients in Korea.

키워드

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