대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제30권5호
  • /
  • Pages.418-427
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  • 2009
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  • 1229-0807(pISSN)
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  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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초음파 치료의 효율성 향상을 위한 초음파 온열 시뮬레이터 개발

The Development of Ultrasonic Hyperthermia Simulator to Improve the Efficiency of Ultrasonic Therapy

  • 유우진 (인제대학교 의생명공학대학 의용공학과) ;
  • 노시철 (인제대학교 의생명공학대학 의용공학과) ;
  • 정동환 (인제대학교 의생명공학대학 의용공학과) ;
  • 박재현 (인제대학교 의생명공학대학 의용공학과) ;
  • 최민주 (제주대학교 의과대학 의학과) ;
  • 최흥호 (인제대학교 의생명공학대학 의용공학과)
  • Yu, W.J. (Department of Biomedical Engineering, Inje University) ;
  • Noh, S.C. (Department of Biomedical Engineering, Inje University) ;
  • Jung, D.W. (Department of Biomedical Engineering, Inje University) ;
  • Park, J.H. (Department of Biomedical Engineering, Inje University) ;
  • Choi, M.J. (Department of Medicine, Medical School, Cheju National University) ;
  • Choi, H.H. (Department of Biomedical Engineering, Inje University)
  • 발행 : 2009.10.31
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초록

As many people are westernizing their life style and food consumption habits, a number of patients who have malignant tumors which grow very rapidly and hazardously destroy the human body are increasing. Ultrasonic hyperthermia is not only one of the tumor treatment methods which employs the non-radioactive ultrasonic waves to increase the temperature at the tumor region up to $40\sim45^{\circ}C$ to destroy and suppress tumor cells but also has been proved by many studies. Due to the rapid development of High Intensity Focused Ultrasound(HIFU), the ultrasound hyperthemia extensively boosts its applications in clinical field. For those reasons, Computed simulation factor should be needed before inspection to patients. To prove efficiency of ultrasonic hyperthermia, precise acoustic field measurement considering tissue characteristics and a heating experiment with tissue mimicking material phantom were conducted for effectiveness of simulation program. Finally, in this study, the computer simulation program verified the anticipated temperature effects induced by ultrasound hyperthermia. In the near future, it is hoped that this simulation program could be utilized to improve the efficiency of ultrasound hyperthermia.

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참고문헌

  1. 보건복지부, "한국 중앙 암 등록 사업 연례 보고서", 2002
  2. F.W. Longo, W.E. Longo, P. Tomashefsky, "Interaction of ultrasound with neoplastic tissue. Local effect on subcutaneously implanted. Furth Columbia rat Wilms' tumor", Urology, vol. 6, pp. 631-634,1975 https://doi.org/10.1016/0090-4295(75)90520-8
  3. J.W. Kim, K.I. Lee, J.M. Han, "Effects of Continuous Therapeutic Ultrasound on Subcutaneous Murine Melanoma", Korea Academy of University Trained Physical Therapists vol. 4, pp. 11-19, 1997
  4. 박중욱, "암 아는만큼 이긴다", 넥서스Books,pp. 24-76,2005
  5. Korea Standard Association, "Medical electrical equipment Part 2 - 37 : Particular requirements for the safety ofultrasonic medical diagnostic and monitoring equipment"
  6. J.A. Jensen, D. Gandhi, W.D.O Brien, "Ultrasound fields in an attenuating medium", In Proc. IEEE Ultrasonic Symp, pp. 943-946, 1993
  7. A. Ahuja, "Ultrasonic attenuation in soft tissues : Reasons for large magnitude and linear frequency dependence", Ultrasonic Imaging, vol. 2, pp. 391-396, 1980 https://doi.org/10.1016/0161-7346(80)90039-5
  8. W.R. Hedrick, L.H. David, E.S. Dale, "Ultrasound Physics and Instrumentation", 3rd edition, Mosby, pp. 249-279,1995
  9. LB. Choi, B.S. Nah, Y. Nagata, A. Shaki and C.W. Song, "Changes in blood flow in normal tissues of rats by hyperthermia", Proc. of the 7th Int., Congress on Hyperthermia oncology,pp. 803-804, 1996
  10. S. Weinbaum, L.M. Jiji, "A new simplified Bioheat Equation for the effect of blood flow on local average tissue temperature", J Biomechanical Eng., vol. 107, pp. 131-139, 1985 https://doi.org/10.1115/1.3138533
  11. D.T. Tompkins, R. Vanderby, SA Klein, WA Bechman, RA Steeves, D.M. Frye, and B.R. Paliwal, "Temperature dependent versus constant rate blood perfusion modelling in ferromagnetic thermo seed hyperthermia:results with a model of the human prostate", Int. J Hyperthermia, vol. 10, pp. 517-536, 1994 https://doi.org/10.3109/02656739409009355
  12. Kremkau FW, "Cancer therapy with ultrasound", A historical review, J Clin Ultrasound, vol. 7, pp. 287-300,1979 https://doi.org/10.1002/jcu.1870070410
  13. W.Q. Lu, J.L. Liu, and Y. Zeng, "Simulation ofthe thermal wave propagation in biological tissues by the dual reciprocity boundary element method", Engineering Analysis with Boundary Elements, vol. 22, pp. 167-174, 1998 https://doi.org/10.1016/S0955-7997(98)00039-3
  14. 한국기술표준원, KS-C-61102, "0.5MHz-5MHz 주파수 영역에서 수중 청음기를 사용한 초음파 음장 측정 및 특성화', 2004
  15. 한국기술표준원, KS-C-60601-2-37, "초음파 진단 및 감시 기기의 안정에 관한 개별 요구 사항", 2005