Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Studies on the Dermal and Ocular Irritation of Prodigiosin Isolated from Zooshikella rubidus

  • Kim, Yong-Sook (Department of Fashion Design Information, Chungbuk National University) ;
  • Choi, Jong-Myoung (Department of Fashion Design Information, Chungbuk National University) ;
  • Yoon, Jung-Hoon (Korea Research Institute of Bioscience and Biotechnology) ;
  • Choi, Myung-Jin (College of Veterinary Medicine, Kyungpook National University) ;
  • Reza, Md. Ahsanur (College of Veterinary Medicine, Kyungpook National University) ;
  • Park, Seung-Chun (College of Veterinary Medicine, Kyungpook National University)
  • Published : 2009.12.01
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Abstract

This study was carried out to investigate the irritation of the prodigiosin isolated from Zooshikella rubidus on the skin and eyes in New Zealand white rabbits. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. Prodigiosin induced severe eye irritation at high concentration (0.5 g/site/ml) but there was no eye irritation at low concentration (0.3 mg/sitel ml). The primary irritation index was calculated from higher concentration (0.5 g/site/ml) to lower concentration (0.3 mg/site/ml). There were found non-irritation or induced mild irritation at lower concentration of prodigiosin application. On the basis of this study, it could be concluded that the prodigiosin may be non-irritant to mild irritant of usual application at lower concentration (0.3 mg/site) resulting it is safe and useful in dyeing technology of fabrics.

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References

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