Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Effects of βig-h3/Chitosan Dressing on Dermal Fibroblast and Wound Healing

βig-h3포함 키토산 상처 도포제의 섬유아세포 증식 및 상처치유 개선 능 평가

  • Cho, Ae-Ri (College of Pharmacy, Duksung Women's University) ;
  • Choi, Hee-Sun (College of Pharmacy, Duksung Women's University)
  • 조애리 (덕성여자대학교 약학대학) ;
  • 최희선 (덕성여자대학교 약학대학)
  • Published : 2009.02.20
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Abstract

${\beta}ig$-h3, is a TGF-${\beta}$-induced gene product, extracellular matrix protein with 68 kDa MW(683 amino acids) and has been known for its possible roles in cell adhesion, spreading, migration and proliferation. To minimize a proteolytic degradation of ${\beta}ig$-h3, ${\beta}ig$-h3 incorporated chitosan sponge was prepared and its effects on fibroblast adhesion and migration were investigated. And its wound healing efficacy was evaluated in deep 2nd degree burn rabbit ear wound model. ${\beta}ig$-h3 enhanced fibroblast adhesion and proliferation. In histological observation, a significant over-proliferation of epidermal regeneration was observed in ${\beta}ig$-h3/chitosan dressing applied wound while epidermal regeneration was not proceeded yet in chitosan only treated wound. ${\beta}ig$-h3/sponge dressing could enhance epidermal regeneration.

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References

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