Journal of the Optical Society of Korea

  • 제13권1호
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  • Pages.166-170
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  • 2009
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  • 1226-4776(pISSN)
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  • 2093-6885(eISSN)
한국광학회 (Optical Society of Korea)
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Hemodynamic Responses of Rat Brain Measured by Near-infrared Spectroscopy During Various Whisker Stimulations

  • Lee, Seung-Duk (Department of Biomedical Engineering, Yonsei University) ;
  • Koh, Dalk-Won (Department of Biomedical Engineering, Yonsei University) ;
  • Kwon, Ki-Woon (Department of Biomedical Engineering, Yonsei University) ;
  • Lee, Hyun-Joo (Department of Physiology, Hallym University) ;
  • Lang, Yiran (Department of Physiology, Hallym University) ;
  • Shin, Hyung-Cheul (Department of Physiology, Hallym University) ;
  • Kim, Beop-Min (Department of Biomedical Engineering, Korea University)
  • 투고 : 2008.08.25
  • 심사 : 2008.12.19
  • 발행 : 2009.03.25
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초록

NIRS (Near-infrared spectroscopy) is a relatively, new, non-invasive, and non-ionizing method of measuring hemodynamic responses in thick biological tissues such as the cerebral cortex. In this study, we measured the hemodynamic responses of the rat barrel cortex to whisker stimulation by using a frequency-domain NIRS system. We designed multiple optical probes comprising multi-mode optical fibers and manipulating arms, both of which can be easily applied to small animals. Various electrical stimulations were applied to rat whiskers at different voltage levels and stimulation frequencies. Our results show that the hemodynamic responses are highly dependent on the stimulation voltage level, and not so much on stimulation frequency. This paper suggests that NIRS technology is highly suitable for the study of small animal brains.

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참고문헌

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피인용 문헌

  1. Depth-dependent cerebral hemodynamic responses following Direct Cortical Electrical Stimulation (DCES) revealed by in vivo dual-optical imaging techniques vol.20, pp.7, 2012, https://doi.org/10.1364/OE.20.006932
  2. Estimation of directional coupling between cortical areas using Near-Infrared Spectroscopy (NIRS) vol.18, pp.6, 2010, https://doi.org/10.1364/OE.18.005730
  3. Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats vol.20, pp.4, 2011, https://doi.org/10.5607/en.2011.20.4.189