Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Prevalence of HPV Infection and HPV Genotype Spectrum among Sexually High-Risk Women in Busan

부산지역 유흥업소 종사 여성의 HPV 감염 및 유전자형 분포 조사

  • Min, Sang-Kee (Division of Epidemiology, Busan Institute of Health and Environment) ;
  • Kim, Sung-Soon (Divison of AIDS, Center for Immunology and Pathology, National Institute of Health, Korea Center for Disease Control & Prevention) ;
  • Choi, Byeong-Sun (Divison of AIDS, Center for Immunology and Pathology, National Institute of Health, Korea Center for Disease Control & Prevention) ;
  • Cho, Kyung-Soon (Division of Epidemiology, Busan Institute of Health and Environment) ;
  • Lee, Joo-Yun (Division of Epidemiology, Busan Institute of Health and Environment) ;
  • Kim, Seong-Joon (Division of Epidemiology, Busan Institute of Health and Environment) ;
  • Bin, Jae-Hun (Division of Epidemiology, Busan Institute of Health and Environment) ;
  • Park, Ho-Kuk (Division of Epidemiology, Busan Institute of Health and Environment)
  • 민상기 (부산광역시보건환경연구원) ;
  • 김성순 (질병관리본부 국립보건연구원 면역병리센터 에이즈.종양바이러스팀) ;
  • 최병선 (질병관리본부 국립보건연구원 면역병리센터 에이즈.종양바이러스팀) ;
  • 조경순 (부산광역시보건환경연구원) ;
  • 이주연 (부산광역시보건환경연구원) ;
  • 김성준 (부산광역시보건환경연구원) ;
  • 빈재훈 (부산광역시보건환경연구원) ;
  • 박호국 (부산광역시보건환경연구원)
  • Published : 2009.02.28
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Abstract

We tried to analyze the HPV prevalence and HPV genotypes of sexually high-risk women living in Busan, the biggest seaport of South Korea. Six hundred sixty women engaging in high-risk occupations participated in this study. The prevalence of HPV infection and HPV genotyping were determined with $MyGene^{(R)}$ HPVDNA chip, which consisted of 16 high-risk HPV genotypes (oncogenic genotypes) and 8 low-risk HPV genotypes. The overall prevalence of HPV infection in this study population was 39.1% (258/660) and the 20's showed the highest prevalence of HPV infection (51.5%). The dominant HPV genotypes including single or multiple HPV-infected women were resulted in HPV-16 (15.9%), -53 (10.2%), -58 (7.7%), -18 (5.2%) in case of high-risk HPV genotype and HPV-70 (10.4%), -6 (4.1%), -11 (2.0%) in case of low-risk HPV genotypes. Remarkably, the proportion of women infected with high-risk HPV genotypes (62.0%) was almost four times higher than those of women infected with low-risk HPV genotypes (14.7%) and high/low-risk HPV genotypes (12.0%). Among the 258 HPV-infected women, single infection was 175, double infection 66, triple infection 12, quadruple infection 4, quintuple infection 1, respectively. Our finding suggests that the introduction and development of effective HPV vaccines should consider the current status of HPV genotypic infection in South Korean women.

부산지역의 유흥업소 종사여성을 대상으로 HPV DNA chip 시험을 통하여 HPV 유병율 및 유전자형 분포를 조사하였다. 총 660건의 자궁경부도찰 검체로부터 258건(양성율 39.1%)이 검출되었으며, 20대에서 가장 높은 유병율을 나타내었다. 양성자의 유전자형 분포는 고위험군 유전자형의 경우 HPV-16 (15.9%), -53 (10.2%), -58 (7.7%), -18 (5.2%)순이었고, 저위험군 유전자형의 경우 HPV-70 (10.4%), -6 (4.1%), -11 Journal of Life Science 2009, Vol. 19. No. 2 239 (2.0%)순이었다. 특이하게 고위험군 감염여성의 분포비(62.0%)가 저위험군(14.7%) 및 고/저위험군 혼합감염(12.0%)보다 4배 가까이 높았다. 전체 양성자중 단일유형 감염자는 175건(67.8%)이고 혼합유형 감염자는 83건(32.2%)이었다. 본 연구 결과 밝혀진 부산지역 유흥업소 종사여성에서 많이 발견되는 HPV 유전자형 분포의 다양성은 국내 도입된 자궁경부암 예방백신의 효과 예측 및 국내 특성에 맞는 다가백신 개발의 기초 자료가 될 수 있을 것으로 사료된다.

Keywords

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