Journal of the Korean Society for Precision Engineering (한국정밀공학회지)

Korean Society for Precision Engineering (한국정밀공학회)
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Development of Bioreactor by Rapid Prototyping Technology

쾌속 조형 기술을 이용한 바이오리액티의 개발

  • Park, Jeong-Hun (Department of Precision Mechanical Engineering, Chungbuk National Univ.) ;
  • Lee, Seung-Jae (BK21 Mechatronics groups, Chungnam National Univ.) ;
  • Lee, In-Hwan (School of Mechanical Engineering, Chungbuk National Univ.) ;
  • Cho, Dong-Woo (Department of Mechanical Engineering, POSTECH) ;
  • Rhie, Jong-Won (Department of Plastic Surgery, College of medicine, Catholic Univ.)
  • 박정훈 (충북대학교 정밀기계공학과) ;
  • 이승재 (충남대학교 BK21 메카트로닉스 사업단) ;
  • 이인환 (충북대학교 기계공학부) ;
  • 조동우 (포항공과대학교 기계공학과) ;
  • 이종원 (가톨릭의대성형외과)
  • Published : 2009.03.01
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Abstract

It has been reported that mechanical stimulation takes a role in improving eel/ growth in skeletal system. Various research groups have been showed their own bioreactors which stimulate cell-seed three-dimensional scaffold. In this study, we hypothesized that the various conditions of mechanical stimulation would affect cell growth and proliferation. To prove our hypothesis, we designed a custom-made bioreactor capable of applying controlled compression to cell-encapsulated scaffolds. This device consisted of a circulation system and a compression system. Each parts of the bioreactor was fabricated using the rapid prototyping technology By using the rapid prototyping technology, we can modify and improve the bioreactor very rapidly For dynamic cell-culture, cell-encapsulated agarose gel was fabricated in 2% concentration. We performed dynamic cell-culture using this agarose gel and developed bioreactor in 3 days.

Keywords

References

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