한방재활의학과학회지 (Journal of Korean Medicine Rehabilitation)

  • 제19권1호
  • /
  • Pages.39-55
  • /
  • 2009
  • /
  • 1229-1854(pISSN)
  • /
  • 2288-4114(eISSN)
한방재활의학과학회 (The society of Korean Medicine Rehabilitation)
권호 표지

좌골신경 압좌 손상 후 전침 및 녹용 약침의 통증 감소와 신경 재생에 관한 실험적 연구

The Experimental Study of Electroacupuncture and Cervi Pantortichum Cornu Pharmacopuncture on Pain Decrease and Nerve Regeneration after Crush Injury of Sciatic Nerve

  • 안혜림 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 양미성 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 신미숙 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 최진봉 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 김선종 (동신대학교 한의과대학 한방재활의학과교실)
  • Ahn, Hye-Lim (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Shin University) ;
  • Yang, Mi-Sung (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Shin University) ;
  • Shin, Mi-Sook (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Shin University) ;
  • Choi, Jin-Bong (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Shin University) ;
  • Kim, Sun-Jong (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Shin University)
  • 투고 : 2008.12.12
  • 심사 : 2009.01.18
  • 발행 : 2009.01.13

⟨ 이전 논문 다음 논문 ⟩

초록

Objectives : This study was designed to evaluate effects of electroacupuncture and Cervi Pantortichum Cornu pharmacopuncture on pain and nerve regeneration after crush injury of sciatic nerve in rats. Methods : We divided the subjects into 5 groups : control group, acupuncture treated group, electroacupuncture treated group, Cervi Pantortichum Cornu pharmacopuncture treated group, electroacupuncture and Cervi Pantortichum Cornu pharmacopuncture group. Hot plate test and degree of Substance P antibody in each group were observed at the 1st, 2nd, 3rd and 5th day. Sciatic function index and change of BDNF immunoreactivity had been estimated at the 7th, 14th, 21st day respectively. Atrophy of the gastrocnemius at the 21st day was observed. Results : All the experimental groups showed significant changes in hot plate test, degree of Substance P antibody, sciatic function index and change of BDNF immunoreactivity compared with control group. Especially, when electroacupuncture and Cervi Pantortichum Cornu pharmacopuncture used together, results were more effective than other groups. Recovery of the gastrocnemius was also the same. Conclusions : It is suggested that electroacupuncture and Cervi Pantortichum Cornu pharmacopuncture may play a significant role on pain decrease and nerve regeneration after crush injury of sciatic nerve in rats and these two treatments could be more effective when used together.

키워드

참고문헌

  1. Wells WE. A review of the chronic pain syndromes etiology, transmission and treatment. Crna. 1993;4:187-98.
  2. Baron R. Peripheral neuropathic pain : from mechanisms to symptoms. Clin J Pain. 2000;16:S12-20. https://doi.org/10.1097/00002508-200003000-00003
  3. 대한침구학회 교재편찬위원회. 침구학(하). 서울:집문당. 2008:176-8.
  4. 이정우 역. 황제내경소문. 서울:여강출판사. 2003;2:553-76.
  5. Ezzo J, Berman B, Hadhazy VA, Jadad AR, Lao L, Singh BB. Is acupuncture effective for the treatment of chronic pain- A sysmatic review. Pain. 2000;86(3):217-25. https://doi.org/10.1016/S0304-3959(99)00304-8
  6. 전국한의과대학 침구경혈학교실. 침구학(상). 서울:집문당. 1998:643-5.
  7. 대한침구학회 교재편찬위원회. 침구학(중). 서울:집문당. 2008:364.
  8. 대한약침학회. 약침요법시술서. 서울:대한약침학회. 2000:13-62.
  9. 전국한의과대학 침구경혈학교실. 침구학(하). 서울:집문당. 1998:1457-67.
  10. 이문호, 손인철. 약침요법의 소개 및 문제점 고찰. 대한침구학회지. 1998;15(2):512.
  11. 박은주, 신정철, 나건호, 이동현, 한상균, 윤여충, 채우석, 조명래. 녹용약침의 퇴행성 슬관절염에 대한 임상적 연구. 대한침구학회지. 2004;21(2):275-86.
  12. 김우영, 백승태, 박준성, 이승태, 김갑성. 녹용 약침으로 호전된 족근통 및 족저 근막염 환자 10례에 대한 임상적 고찰. 대한침구학회지. 2004;21(6):121-6.
  13. 박준성, 김우영, 백승태, 이승덕, 김갑성. 녹용 약침으로 치료한 De Quervain's Disease 4례 증례보고. 대한침구학회지. 2004;21(6):256-67.
  14. Baron R. Neuropathic pain. The long path from mechanisms to mechanism-based treatment. Der Anaesthesist. 2000;49:373-86. https://doi.org/10.1007/s001010070105
  15. 황병길, 유기용, 민병일, 김지훈, 박동석. 신경병증성 통증에 대한 전침자극 효과의 연구. 대한침구학회지. 2001;18(6):215-24.
  16. 이형석, 민병일, 황병길, 박동석, 이순걸. Tail model의 기계적 이질통에 대한 전침 자극의 효과 및 교감신경계의 관여기전. 대한침구학회지. 2003;20(1):177-90.
  17. 윤정안, 유윤조, 김강산, 김경식, 김흥훈, 김대중, 조남근. 전침의 Parameters에 대한 실험적 연구. 대한침구학회지. 2005;22(1):145-53.
  18. 박상민, 이윤호, 강성길. 전침이 신경병증성 냉이질통 발생 억제에 미치는 영향. 대한침구학회지. 2005;22(6):27-36.
  19. 김성남, 김성철, 최회강, 소기숙, 임정아, 황우준, 문형철, 최성용, 이상관, 나창수. 환도 오공 약침 자극이 백서의 신경병증성 동통 억제에 미치는 영향. 대한침구학회지. 2004;21(3):145-67.
  20. 이동현, 윤대환, 나창수, 윤여충. 환도 봉독 약침 자극이 백서의 신경병증성 동통 억제에 미치는 영향. 대한침구학회지. 2005;22(5):67-77.
  21. 김선종, 정문재, 박성혁, 김정환, 염승룡, 권영달, 송용선. 백굴채 약침이 백서의 말초 신경병증성 통증 억제에 미치는 영향. 한방재활의학과학회지. 2007;17(2):1-16.
  22. Subbanna PK, Prasanna CG, Gunale BK, Tyagi MG. Acetyl salicylic acid augments functional recovery following sciatic nerve crush in mice. J Brachial Plex Peripher Nerve Inj. 2007;4:2-3.
  23. 오홍근. 통증의학. 서울:군자출판사. 1995:1-32.
  24. 김재효. 실험적 말초신경 손상 후 신경증을 일으킨 백서의 통증반응에 미치는 전침의 효과. 원광대학교 대학원 석사학위논문. 1997:21-38.
  25. 이배환, 손진훈. 만성 동통의 진단 및 치료와 심리학. 한국심리학회 춘계심포지움. 1996:227-8.
  26. Rochkind S, Nissan M, Alon M, Shamir M, Salame K. Effects of laser irradiation on the spinal cord for the regeneration of crushed peripheral nerve in rats. Lasers in Surg Med. 2001;28:216-9. https://doi.org/10.1002/lsm.1041
  27. Dray A, Urban L, Dickenson A. Pharmacology of pain. Trends in Pharmacal Sci. 1994;15:190-7. https://doi.org/10.1016/0165-6147(94)90147-3
  28. Hulsebosch CE. Recent advances in pathophysiology and treatment of spinal cord injury. Adv Physiol Educ. 2002;26 :238-55. https://doi.org/10.1152/advan.00039.2002
  29. 변부형, 임사비나, 이승우. 좌골신경통의 침구 치료. 제한동의학술원 논문집. 1999;4(1):558-65
  30. 신민교. 임상본초학. 서울:영림사. 2000:204-5.
  31. 김창민 외. 중약대사전. 서울:정담. 1997;2:794-9.
  32. 최도영. 녹용수침이 빈혈 가토에 미치는 영향. 경희대학교 논문집. 서울. 1986;9:501-16.
  33. 박종현. 녹용수침이 손상간에 마치는 영향. 경희대학교 논문집. 서울. 1994;10:627-42.
  34. 허정욱. 녹용수침이 흰쥐의 갑성선기능항진증에 미치는 영향. 동국대학교 한의과 대학원 박사학위 논문. 1994:1-19.
  35. 한상원. 녹용약침이 골형성에 미치는 영향. 대한침구학회지. 2001;18(5):135-46.
  36. 羅永芬 主編. 脾穴學. 上海: 上海科學技術出版社. 1998:186-7.
  37. Li X, Clark JD. Hyperalgesia during opioid abstinence: mediation by glutamate and substance P. Anesth Analg. 2002;95:979-84. https://doi.org/10.1097/00000539-200210000-00035
  38. Bhalodia VM, Sestokas AK, Tomak PR, Schwartz DM. Transcranial electric motor evoked potential detection of compressional peroneal nerve injury in the lateral decubitus position. J Clin Monit Comput. 2008;22:319-26. https://doi.org/10.1007/s10877-008-9136-x
  39. Zhang RX, Mi ZP, Qiao JT. Change of spinal substance P, calcitonin gene-peptide, somatostatin, Met-enkephalin and neurotensin in rats in response to formalin induced pain. Regul Pept. 1994;51:25-32. https://doi.org/10.1016/0167-0115(94)90131-7
  40. Duggan AW, Hendry IA, Green LJ, Morton CR, Zao ZQ. Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat. Brain Res. 1988;461:261-73.
  41. Ashton IK, Ashton BA, Gibson SJ, Polak JM, Jaffray DC, Eisenstein SM. Morphological basis for back pain: the demonstration of nerve firbers and neuropeptides in the lumbar facet joint capsule but not in ligamentum flavum. J Orthop Res. 1992;10:72-8. https://doi.org/10.1002/jor.1100100109
  42. Pernow B. Substance P. Pharmacol Rev. 1983;35:86-141.
  43. Jessel TM, Tsungo A, Kanazawa I, Otsuka M. Substance P depletion in the dorsal horm of rat spinal cord after section of the peripheral processes of primary sensory neurons. Brain Res. 1979;168:247-95. https://doi.org/10.1016/0006-8993(79)90167-7
  44. De Medinaceli L, Derenzo E, Wyatt RJ. Rat sciatic functional index data management system with digitized input. Computers and Viomedical Research. 1984;17:185-92. https://doi.org/10.1016/0010-4809(84)90031-4
  45. Hare GMT, Evans PJ, Mackinnon SE, Best TJ, Szalai JP, Hunter RT. Walking track analysis: A long-term assessment of peripheral nerve recovery. Plast Reconstr Surg. 1992;89:251-8. https://doi.org/10.1097/00006534-199202000-00009
  46. Shen N, Zhu J. Application of sciatic function index in nerve functional assessment. Microsurgery. 1995;16:552-5. https://doi.org/10.1002/micr.1920160809
  47. Meek MF, den Dunnen WFA, Robinson PH, Schakenraad JM. Evaluation of functional nerve recovery after reconstruction with a polu (DL-lactide-ecarprolactone) nerve guide, filled with midified denatured muscle tissue. Microsurgery. 1996;17:555-61. https://doi.org/10.1002/(SICI)1098-2752(1996)17:10<555::AID-MICR5>3.0.CO;2-P
  48. Ashley Z, Salmons S, Boncompagni S, Protasi F, Russold M, Lamnuller H, Mayer W, Sutherland H, Jarvis JC. Effects of chronic electrical stimulation on long-term muscles of the rabbit hind limb. J Muscle Res Cell Motil. 2007;28:203-7. https://doi.org/10.1007/s10974-007-9119-4
  49. McAllister AK, Kats LC, Lo DC. Neurotrophic and synaptic plasticity. Annu Rev Neurosci. 1999;22:295-318. https://doi.org/10.1146/annurev.neuro.22.1.295
  50. Neeper SA, Pinilla FG, Chol J, Cotman C. Exercise and brain neurotrophins. Nature. 1995;373:6510. https://doi.org/10.1038/373109a0
  51. English AW, Schwartz G, Meador W, Sabatier MJ, Mulligan A. Electrical stimulation promotes peripheral axon regeneration by enhanced neuronal neurotropin signaling. Dev Neurobiol. 2007;67:158-72. https://doi.org/10.1002/dneu.20339
  52. Shelton DL, Reichardt LF. Expression of ${\beta}-nerve$ growth factor gene correlates with the density of sympathetic immervation in effector organs. Proc Natl Acid Sci USA. 1984;81:7951-5. https://doi.org/10.1073/pnas.81.24.7951
  53. Hyman C, Hofer M, Barde YA, Juhasz M, Yancopoulos GD, Squinto SP, Lindsay RM. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia. Nature. 1991;350:230-2. https://doi.org/10.1038/350230a0
  54. Mamounas LA, Blue ME, Siuclak JA, Altar CA. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J Neurosci. 1995;15:7929-39.
  55. Ventimiglia R, Mather PE, Jones BE, Lindsay RM. The neurotropins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro. Eur J Neurosci. 1995;7:213-22. https://doi.org/10.1111/j.1460-9568.1995.tb01057.x
  56. Meyer M, Matsuoka I, Wetmore C, Olson L, Thoenen H. Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J Cell Biol. 1992;119:45-54. https://doi.org/10.1083/jcb.119.1.45